Rice R J, Biddle J W, JeanLouis Y A, DeWitt W E, Blount J H, Morse S A
J Infect Dis. 1986 Feb;153(2):340-5. doi: 10.1093/infdis/153.2.340.
Between January 1983 and October 1984, 446 cases of infection due to chromosomally mediated resistance in Neisseria gonorrhoeae (CMRNG) were reported in 23 states. Eighty percent were detected as primary penicillin or ampicillin treatment failures. Gonococcal isolates were submitted from 175 (40%) for confirmation of resistance, susceptibility testing, gonococcal strain typing using monoclonal antibodies specific for outer membrane Protein I, and auxotyping. All were typed as Protein I serogroup IB (WII/WIII), and the majority were proline or prototrophic auxotypes. All were resistant in vitro to less than 1 microgram/ml of either penicillin or tetracycline. Comparing CMRNG with penicillinase-producing Neisseria gonorrhoeae (PPNG), we found that CMRNG were significantly more resistant to tetracycline and erythromycin, but PPNG were more resistant to penicillin (P less than .01). Because of increasing reports of gonococcal resistance in the United States, improved surveillance of clinical and laboratory resistance is needed in support of control and treatment recommendations for gonorrhea.
1983年1月至1984年10月期间，美国23个州报告了446例由染色体介导耐药的淋病奈瑟菌（CMRNG）引起的感染病例。其中80%被检测为青霉素或氨苄西林初治失败。从175例（40%）中提交了淋球菌分离株，用于确认耐药性、药敏试验、使用针对外膜蛋白I的单克隆抗体进行淋球菌菌株分型以及营养分型。所有菌株均被分型为蛋白I血清群IB（WII/WIII），大多数为脯氨酸或原养型营养型。所有菌株在体外对低于1微克/毫升的青霉素或四环素均耐药。将CMRNG与产青霉素酶淋病奈瑟菌（PPNG）进行比较，我们发现CMRNG对四环素和红霉素的耐药性显著更高，但PPNG对青霉素的耐药性更高（P<0.01）。由于美国淋病奈瑟菌耐药报告不断增加，需要加强对临床和实验室耐药情况的监测，以支持淋病的控制和治疗建议。
