Ceftriaxone in the treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.
作者信息
Rajan V S, Sng E H, Thirumoorthy T, Goh C L
出版信息
Br J Vener Dis. 1982 Oct;58(5):314-6. doi: 10.1136/sti.58.5.314.
Abstract
Ceftriaxone, a third generation cephalosporin, was used in a single intramuscular dose with oral probenecid to treat 124 men with infections due to non-penicillinase-producing Neisseria gonorrhoeae (non-PPNG) and 64 men with infections due to PPNG. Three different doses of ceftriaxone were used--125 mg, 62.5 mg, ad 32.5 mg, and 32.5. The cure rate for all PPNG infections with the different doses was 100%. The cure rate for the non-PPNG infections with ceftriaxone 125 mg was 100%; those for non-PPNG infections treated with ceftriaxone 62.5 mg and 32.5 mg were 96.2% and 97.3% respectively. The 160 strains of non-PPNG and 60 strains of PPNG isolated were all susceptible to ceftriaxone with minimum inhibitory concentrations of 0.008 microgram/ml. These results are compared with those using kanamycin 2 g. Ceftriaxone is a safe and effective treatment for PPNG and non-PPNG infections.
摘要
相似文献
1
Ceftriaxone in the treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.
Br J Vener Dis. 1982 Oct;58(5):314-6. doi: 10.1136/sti.58.5.314.
2
Single dose cefoxitin in treating uncomplicated gonorrhoea caused by penicillinase producing Neisseria gonorrhoeae (PPNG) and non-PPNG strains.
Genitourin Med. 1986 Aug;62(4):224-7. doi: 10.1136/sti.62.4.224.
3
[Ceftriaxone as a single-dose treatment for male gonococcal urethritis].
Jpn J Antibiot. 1984 Nov;37(11):2169-73.
4
Randomised comparative study of ceftriaxone and spectinomycin in gonorrhoea.
Genitourin Med. 1985 Apr;61(2):106-8. doi: 10.1136/sti.61.2.106.
5
HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.
Br J Vener Dis. 1980 Aug;56(4):255-8. doi: 10.1136/sti.56.4.255.
6
Single 1 g dose of cefotaxime in the treatment of infections due to penicillinase-producing strains of Neisseria gonorrhoeae.
Br J Vener Dis. 1983 Apr;59(2):100-2. doi: 10.1136/sti.59.2.100.
7
Comparison of ceftriaxone with cefoxitin in the treatment of penicillin-resistant gonococcal urethritis.
Br J Vener Dis. 1983 Jun;59(3):176-8. doi: 10.1136/sti.59.3.176.
8
Antimicrobial sensitivity of Neisseria gonorrhoeae. Comparison of penicillinase producing and non-penicillinase producing strains.
Br J Vener Dis. 1983 Oct;59(5):289-92. doi: 10.1136/sti.59.5.289.
9
10
Susceptibility of penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae isolated in Durban, South Africa, to 15 beta-lactam antibiotics.
Sex Transm Dis. 1988 Jan-Mar;15(1):30-4. doi: 10.1097/00007435-198801000-00007.
引用本文的文献
1
Efficacy and Safety of Injectable and Oral Antibiotics in Treating Gonorrhea: A Systematic Review and Network Meta-Analysis.
J Clin Med. 2019 Dec 11;8(12):2182. doi: 10.3390/jcm8122182.
2
A Brief History of Evolving Diagnostics and Therapy for Gonorrhea: Lessons Learned.
Clin Infect Dis. 2018 Sep 28;67(8):1294-1299. doi: 10.1093/cid/ciy271.
3
The use of cephalosporins for gonorrhea: the impending problem of resistance.
Expert Opin Pharmacother. 2009 Mar;10(4):555-77. doi: 10.1517/14656560902731993.
4
Cephalosporin-probenecid drug interactions.
Clin Pharmacokinet. 1993 Apr;24(4):289-300. doi: 10.2165/00003088-199324040-00003.
5
Comparison of ciprofloxacin and ceftriaxone as single-dose therapy for uncomplicated gonorrhea in women.
Antimicrob Agents Chemother. 1993 Aug;37(8):1670-3. doi: 10.1128/AAC.37.8.1670.
6
Ceftriaxone. A review of its antibacterial activity, pharmacological properties and therapeutic use.
Drugs. 1984 Jun;27(6):469-527. doi: 10.2165/00003495-198427060-00001.
7
Antimicrobial sensitivity of Neisseria gonorrhoeae. Comparison of penicillinase producing and non-penicillinase producing strains.
Br J Vener Dis. 1983 Oct;59(5):289-92. doi: 10.1136/sti.59.5.289.
8
Rosoxacin in the treatment of uncomplicated gonorrhoea in men.
Br J Vener Dis. 1984 Aug;60(4):231-4. doi: 10.1136/sti.60.4.231.
9
Efficacy of ofloxacin in uncomplicated gonorrhoea.
Infection. 1986;14 Suppl 4:S311-3. doi: 10.1007/BF01661304.
10
Cefodizime in serum and skin blister fluid after single intravenous and intramuscular doses in healthy volunteers.
Antimicrob Agents Chemother. 1987 Nov;31(11):1822-5. doi: 10.1128/AAC.31.11.1822.
本文引用的文献
1
Comparison of methods for the detection of penicillinase-producing Neisseria gonorrhoeae.
Br J Vener Dis. 1980 Oct;56(5):311-3. doi: 10.1136/sti.56.5.311.
2
Comparative in vitro activity of 8 cephalosporins on 109 strains of Neisseria gonorrhoeae and 60 strains of Neisseria meningitidis.
Chemotherapy. 1981;27 Suppl 1:19-24. doi: 10.1159/000238024.
3
HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae.
Br J Vener Dis. 1980 Aug;56(4):255-8. doi: 10.1136/sti.56.4.255.
4
The efficacy of cefuroxime for the treatment of acute gonorrhoea in men.
Br J Vener Dis. 1978 Jun;54(3):165-7. doi: 10.1136/sti.54.3.165.
5
Epidemiology and treatment of gonorrhoea caused by penicillinase-producing strains in Liverpool.
Br J Vener Dis. 1978 Feb;54(1):28-35. doi: 10.1136/sti.54.1.28.
Zotero 插件