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青少年特发性脊柱侧弯患儿视交叉上核-松果体系统的生物电活动

Bioelectric activity in the suprachiasmatic nucleus-pineal gland system in children with adolescent idiopathic scoliosis.

作者信息

Pinchuk Dmitry Yu, Bekshaev Sergey S, Bumakova Svetlana A, Dudin Mikhail G, Pinchuk Olga D

机构信息

Human Brain Research Centre, Finlandsky pr. 4-A, Office 901, St. Petersburg 194044, Russia ; Ogonyok Rehabilitation Center of Pediatric Orthopedics and Traumatology, St. Petersburg Highway 101, St. Petersburg 198515, Russia.

Human Brain Research Centre, Finlandsky pr. 4-A, Office 901, St. Petersburg 194044, Russia ; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Toreza st., 44, St. Petersburg 194223, Russia.

出版信息

ISRN Orthop. 2012 Aug 28;2012:987095. doi: 10.5402/2012/987095. eCollection 2012.

DOI:10.5402/2012/987095
PMID:24977086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4063198/
Abstract

The purpose of this work is to identify a role of the pineal gland/suprachiasmatic nucleus system in adolescent idiopathic scoliosis (AIS) aetiology and pathogenesis. To analyze electroencephalograms of 292 children with AIS and in 46 healthy subjects, a processing method was used to assess three-dimensional coordinates of electric equivalent dipole sources (EEDSs) within the brain. Amounts of EEDSs in the pineal gland and suprachiasmatic nucleus (SCN) area were assessed in different age groups and during the progress of orthopaedic pathology. It was shown that children with AIS, compared with healthy children, were characterized by a higher level of electric activity (as judged by EEDS values) in the pineal gland area. It was also revealed that the number of EEDS in the pineal gland area increases significantly with increased severity of spinal deformation, while their number in the suprachiasmatic nucleus (SCN) area decreases compared with the number in healthy peers. Changes in electric activity and changes in the pineal gland and SCN area suggest that mechanisms of AIS aetiology and pathogenesis involve functional disturbances in brain areas responsible for the formation and maintenance of normal biorhythms, including osteogenesis and bone growth.

摘要

这项工作的目的是确定松果体/视交叉上核系统在青少年特发性脊柱侧凸（AIS）病因学和发病机制中的作用。为了分析292例AIS患儿和46例健康受试者的脑电图，采用一种处理方法来评估脑内电等效偶极子源（EEDSs）的三维坐标。在不同年龄组以及骨科病理进展过程中，评估松果体和视交叉上核（SCN）区域的EEDSs数量。结果显示，与健康儿童相比，AIS患儿松果体区域的电活动水平较高（根据EEDS值判断）。还发现，随着脊柱畸形严重程度的增加，松果体区域的EEDs数量显著增加，而与健康同龄人相比，视交叉上核（SCN）区域的EEDs数量减少。电活动的变化以及松果体和SCN区域的变化表明，AIS病因学和发病机制涉及负责正常生物节律形成和维持的脑区功能紊乱，包括骨生成和骨骼生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/412909b870c7/ISRN.ORTHOPEDICS2012-987095.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/8dfdf83ca8ce/ISRN.ORTHOPEDICS2012-987095.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/039d18b6a2b5/ISRN.ORTHOPEDICS2012-987095.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/0f8665b5aa20/ISRN.ORTHOPEDICS2012-987095.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/dc4cad077491/ISRN.ORTHOPEDICS2012-987095.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/412909b870c7/ISRN.ORTHOPEDICS2012-987095.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/8dfdf83ca8ce/ISRN.ORTHOPEDICS2012-987095.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/039d18b6a2b5/ISRN.ORTHOPEDICS2012-987095.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/0f8665b5aa20/ISRN.ORTHOPEDICS2012-987095.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/dc4cad077491/ISRN.ORTHOPEDICS2012-987095.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95ec/4063198/412909b870c7/ISRN.ORTHOPEDICS2012-987095.005.jpg

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本文引用的文献

1
The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis (AIS).褪黑素在青少年特发性脊柱侧凸（AIS）发病机制中的作用。
Eur Spine J. 2011 May;20 Suppl 1(Suppl 1):S68-74. doi: 10.1007/s00586-011-1750-5. Epub 2011 Mar 18.
2
Estrogen cross-talk with the melatonin signaling pathway in human osteoblasts derived from adolescent idiopathic scoliosis patients.雌激素与青少年特发性脊柱侧凸患者来源的人成骨细胞中褪黑素信号通路的相互作用。
J Pineal Res. 2008 Nov;45(4):383-93. doi: 10.1111/j.1600-079X.2008.00603.x. Epub 2008 May 26.
3
Concepts on the pathogenesis of adolescent idiopathic scoliosis. Bone growth and mass, vertebral column, spinal cord, brain, skull, extra-spinal left-right skeletal length asymmetries, disproportions and molecular pathogenesis.
青少年特发性脊柱侧凸的发病机制概念。骨骼生长与质量、脊柱、脊髓、脑、颅骨、脊柱外左右骨骼长度不对称、比例失调及分子发病机制。
Stud Health Technol Inform. 2008;135:3-52.
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Pineal gland metabolism in patients with adolescent idiopathic scoliosis.
J Bone Joint Surg Br. 2007 Jan;89(1):66-71. doi: 10.1302/0301-620X.89B1.18058.
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Pathological mechanism of idiopathic scoliosis: experimental scoliosis in pinealectomized rats.特发性脊柱侧凸的病理机制：松果体切除大鼠的实验性脊柱侧凸
Eur Spine J. 2005 Nov;14(9):843-8. doi: 10.1007/s00586-004-0806-1. Epub 2005 Apr 30.
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The effects of exposure to intense, 24 h light on the development of scoliosis in young chickens.暴露于持续24小时的强光下对雏鸡脊柱侧弯发展的影响。
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[Possible role of the pineal gland in the pathogenesis of idiopathic scoliosis. Experimental and clinical studies].[松果体在特发性脊柱侧凸发病机制中的可能作用。实验与临床研究]
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