Noguchi T, Sugisaki T, Kudo M, Satoh I
Brain Res. 1986 May;391(2):161-72. doi: 10.1016/0165-3806(86)90279-8.
The suprachiasmatic nucleus (SCN) and the pineal body in 3 types of inherited hormone-deficient mice, the dw, lit and hyt mice were examined by morphological, morphometric and biochemical techniques. In the dw and lit mice the SCN was underdeveloped. In the ventral part of the SCN, where most of the retinal fibers appeared to terminate, both cell number and cell size were decreased, although the size of the SCN was unaltered. In addition, the pineal bodies of both mice were morphologically underdeveloped and showed low levels of N-acetyltransferase activity. In contrast, the hyt SCN was comparable to the normal controls in every respect. The hyt pineal was well developed and showed levels of enzyme activity comparable to the controls. However, in all the deficient mice, the optic nerve appeared to be normal in morphological and biochemical studies. These results suggest that the underdevelopment of the pineal body, the reduced levels of spontaneous locomotion and the indistinct diurnal periodicity of the dw and lit mice might be related to the retarded neuronal growth of the SCN, and that growth hormone likely is indispensable for the development of the SCN.
运用形态学、形态计量学和生物化学技术，对3种遗传性激素缺乏小鼠（dw、lit和hyt小鼠）的视交叉上核（SCN）和松果体进行了检查。在dw和lit小鼠中，SCN发育不全。在SCN的腹侧部分，大多数视网膜纤维似乎在此处终止，尽管SCN的大小未改变，但细胞数量和细胞大小均减少。此外，这两种小鼠的松果体在形态上发育不全，且N - 乙酰转移酶活性水平较低。相比之下，hyt SCN在各方面均与正常对照相当。hyt松果体发育良好，酶活性水平与对照相当。然而，在所有缺陷小鼠中，视神经在形态学和生物化学研究中似乎均正常。这些结果表明，dw和lit小鼠的松果体发育不全、自发活动水平降低以及昼夜节律不明显可能与SCN神经元生长迟缓有关，并且生长激素可能对SCN的发育不可或缺。
