Decullier Evelyne, Huot Laure, Chapuis François R
Hospices Civils de Lyon, Pôle Information Médicale Evaluation Recherche, Unité de Recherche Clinique, Lyon, France; Université de Lyon, RECIF, EAM Santé Individu Société 4128, Lyon, France; Université Lyon 1, Lyon, France.
PLoS One. 2014 Jun 30;9(6):e99561. doi: 10.1371/journal.pone.0099561. eCollection 2014.
The fate of clinical research projects funded by a grant has been investigated, but there is no information on the projects which did not receive funding. The fate of these projects is not known: do they apply for and/or receive funding from other sources or are they carried out without specific funding?
The aim of the study was to describe all clinical research projects submitted to a French national funding scheme (PHRC 2000) and to assess project initiation, completion and publication status taking into account whether or not they received funding.
This study is a retrospective cohort. The initial project characteristics were retrieved from the submission files and follow-up information was collected from the primary investigator. The percentages of projects started, completed and published were studied.
A total of 481 projects were studied. Follow-up information was obtained for 366. Overall, 185 projects were initiated (51%); 139 of them were funded by the PHRC 2000 or other sources. The most commonly cited reason for not initiating a project was a lack of funding. Subsequently, 121 of the projects initiated were completed (65%). Accrual difficulties were the main reason cited to explain why studies were stopped prematurely or were still ongoing. Finally, 88 of the completed projects were published (73%). Amongst the completed projects, the only factor explaining publication was the statistical significance of the results.
Obtainment of funding was a determining factor for project initiation. However, once initiated, the funding did not influence completion or publication.
由一项拨款资助的临床研究项目的命运已得到调查，但对于未获得资助的项目却没有相关信息。这些项目的命运未知：它们是否申请和/或从其他来源获得资助，或者它们是否在没有特定资金的情况下开展？
本研究的目的是描述提交给一项法国国家资助计划（PHRC 2000）的所有临床研究项目，并考虑项目是否获得资助来评估项目的启动、完成和发表情况。
本研究为回顾性队列研究。从提交文件中检索初始项目特征，并从主要研究者处收集随访信息。研究启动、完成和发表的项目百分比。
共研究了481个项目。获得了366个项目的随访信息。总体而言，185个项目启动（51%）；其中139个由PHRC 2000或其他来源资助。未启动项目最常被提及的原因是缺乏资金。随后，启动的121个项目完成（65%）。入组困难是解释研究为何提前停止或仍在进行的主要原因。最后，88个完成的项目发表（73%）。在完成的项目中，解释发表情况的唯一因素是结果的统计学显著性。
获得资金是项目启动的决定性因素。然而，一旦启动，资金并不影响完成或发表。
