Sun Fangui, Sebastiani Paola, Schupf Nicole, Bae Harold, Andersen Stacy L, McIntosh Avery, Abel Haley, Elo Irma T, Perls Thomas T
From the 1Department of Biostatistics, School of Public Health, Boston University, Boston, MA; 2Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY; 3New England Centenarian Study, Geriatrics Section, School of Medicine, Boston University Medical Center, Boston, MA; 4Division of Biostatistics, Washington University in St Louis, St Louis, MO; and 5Population Studies Center, University of Pennsylvania, Philadelphia, PA.
Menopause. 2015 Jan;22(1):26-31. doi: 10.1097/GME.0000000000000276.
This study investigated the association between maternal age at birth of last child and likelihood of survival to advanced age.
This was a nested case-control study using Long Life Family Study data. Three hundred eleven women who survived past the oldest 5th percentile of survival (according to birth cohort-matched life tables) were identified as cases, and 151 women who died at ages younger than the top 5th percentile of survival were identified as controls. A Bayesian mixed-effect logistic regression model was used to estimate the association between maternal age at birth of last child and exceptional longevity among these 462 women.
We found a significant association for older maternal age, whereby women who had their last child beyond age 33 years had twice the odds for survival to the top 5th percentile of survival for their birth cohorts compared with women who had their last child by age 29 years (age between 33 and 37 y: odds ratio, 2.08; 95% CI, 1.13 to 3.92; older age: odds ratio, 1.92; 95% CI, 1.03 to 3.68).
This study supports findings from other studies demonstrating a positive association between older maternal age and greater odds for surviving to an unusually old age.
本研究调查了生育最后一个孩子时的母亲年龄与活到高龄的可能性之间的关联。
这是一项利用长寿家庭研究数据进行的巢式病例对照研究。311名存活超过生存年龄第95百分位数（根据出生队列匹配生命表）的女性被确定为病例，151名在生存年龄前5百分位数之前死亡的女性被确定为对照。采用贝叶斯混合效应逻辑回归模型来估计这462名女性中生育最后一个孩子时的母亲年龄与超长寿命之间的关联。
我们发现母亲年龄较大存在显著关联，即生育最后一个孩子年龄超过33岁的女性，与生育最后一个孩子年龄在29岁及以下的女性相比，其出生队列存活到第95百分位数的几率高出两倍（33至37岁：比值比，2.08；95%置信区间，1.13至3.92；年龄更大：比值比，1.92；95%置信区间，1.03至3.68）。
本研究支持了其他研究的结果，即母亲年龄较大与活到异常高龄的几率增加呈正相关。
