The Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA; G.H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA; The Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Boston University School of Medicine, Department of Medicine, Boston, MA, USA.
Neurosci Lett. 2022 Jul 27;784:136737. doi: 10.1016/j.neulet.2022.136737. Epub 2022 Jun 13.
Extended maternal age has been suggested as marker of delayed age-associated disabilities. We use the Long Life Family Study (LLFS) offspring generation to investigate the association between extended maternal age at last childbirth and healthy-aging endophenotypes. We hypothesize that women with extended maternal age at last childbirth will exhibit healthier endophenotype profiles compared to younger mothers. The association between maternal age and age-related endophenotypes previously derived in LLFS was assessed using Generalized Estimating Equations to adjust for relatedness. The quartiles of the maternal age at last childbirth were modeled as the independent variables. Univariate analyses tested the association between maternal age at last childbirth and age at clinical assessment, education, field center, Apolipoprotein E (APOE) genotype, depression, stress, smoking and successful pregnancies. Only the variables significantly associated in the univariate analyses were considered in secondary multivariate analyses. Univariate analyses showed that compared to older mothers (age at last birth ≥35), mothers 30 years old or younger at last childbirth are less educated (12 ± 3 years versus 13 ± 3 years) and have a higher frequency of smoking (9% versus 3% for maternal age ≥35). Results showed that older mothers (age at last birth ≥31-34 or ≥ 35) demonstrated significantly better cognitive profiles (p = 0.017 and p = 0.021 respectively) compared with mothers with last childbirth age ≤30. Later maternal age among women from long-life families is associated with a better cognitive profile, supporting the hypothesis that later age at childbirth may be a marker for healthy aging.
高龄产妇被认为是与年龄相关的残疾延迟发生的标志。我们使用长寿家庭研究（LLFS）的后代群体来研究最后一次分娩时产妇年龄与健康衰老表型之间的关系。我们假设，与年轻母亲相比，最后一次分娩时产妇年龄较大的女性将表现出更健康的表型特征。先前在 LLFS 中得出的产妇年龄与年龄相关表型之间的关联使用广义估计方程进行评估，以调整相关性。将最后一次分娩时产妇年龄的四分位数作为自变量进行建模。单变量分析测试了最后一次分娩时产妇年龄与临床评估年龄、教育程度、研究中心、载脂蛋白 E (APOE) 基因型、抑郁、压力、吸烟和成功妊娠之间的关联。只有在单变量分析中显著相关的变量才会被纳入次要多变量分析。单变量分析显示，与年龄较大的母亲（最后一次分娩年龄≥35 岁）相比，最后一次分娩年龄在 30 岁或更年轻的母亲受教育程度较低（12±3 岁比 13±3 岁），吸烟频率更高（9%比 3%，对于最后一次分娩年龄≥35 岁的母亲）。结果表明，与最后一次分娩年龄≤30 的母亲相比，年龄较大的母亲（最后一次分娩年龄≥31-34 岁或≥35 岁）表现出明显更好的认知特征（p=0.017 和 p=0.021）。来自长寿家庭的女性较晚的生育年龄与更好的认知特征相关，这支持了生育年龄较晚可能是健康衰老的标志这一假设。
