Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Geriatrics Section, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
J Alzheimers Dis. 2021;79(1):117-125. doi: 10.3233/JAD-201113.
The Long Life Family Study (LLFS) is a family based, prospective study of healthy aging and familial longevity. The study includes two assessments of cognitive function that were administered approximately 8 years apart.
To test whether APOE genotype is associated with change of cognitive function in older adults.
We used Bayesian hierarchical models to test the association between APOE alleles and change of cognitive function. Six longitudinally collected neuropsychological test scores were modelled as a function of age at enrollment, follow-up time, gender, education, field center, birth cohort indicator (≤1935, or >1935), and the number of copies of ɛ2 or ɛ4 alleles.
Out of 4,587 eligible participants, 2,064 were male (45.0%), and age at enrollment ranged from 25 to 110 years, with mean of 70.85 years (SD: 15.75). We detected a significant cross-sectional effect of the APOEɛ4 allele on Logical Memory. Participants carrying at least one copy of the ɛ4 allele had lower scores in both immediate (-0.31 points, 95% CI: -0.57, -0.05) and delayed (-0.37 points, 95% CI: -0.64, -0.10) recall comparing to non-ɛ4 allele carriers. We did not detect any significant longitudinal effect of the ɛ4 allele. There was no cross-sectional or longitudinal effect of the ɛ2 allele.
The APOEɛ4 allele was identified as a risk factor for poorer episodic memory in older adults, while the APOEɛ2 allele was not significantly associated with any of the cognitive test scores.
长寿家族研究（LLFS）是一项针对健康衰老和家族长寿的基于家庭的前瞻性研究。该研究包括两次大约相隔 8 年的认知功能评估。
检验 APOE 基因型是否与老年人认知功能变化有关。
我们使用贝叶斯层次模型来检验 APOE 等位基因与认知功能变化之间的关联。将 6 项纵向收集的神经心理学测试得分作为入组时的年龄、随访时间、性别、教育程度、研究中心、出生队列指标（≤1935 年或>1935 年）以及 ɛ2 或 ɛ4 等位基因的数量的函数进行建模。
在 4587 名符合条件的参与者中，2064 名是男性（45.0%），入组年龄从 25 岁到 110 岁，平均年龄为 70.85 岁（标准差：15.75 岁）。我们检测到 APOEɛ4 等位基因对逻辑记忆的显著横断面效应。携带至少一个 ɛ4 等位基因的参与者在即时（-0.31 分，95%置信区间：-0.57，-0.05）和延迟（-0.37 分，95%置信区间：-0.64，-0.10）回忆中得分均较低，而非 ɛ4 等位基因携带者。我们没有检测到 ɛ4 等位基因的任何显著纵向效应。ɛ2 等位基因没有横断面或纵向效应。
APOEɛ4 等位基因被确定为老年人情景记忆较差的风险因素，而 APOEɛ2 等位基因与任何认知测试得分均无显著关联。
