Melby K, Faegri A
Department of Medical Microbiology, Ullevaal University Hospital, Oslo, Norway.
APMIS. 1989 Apr;97(4):347-50.
One hundred non-beta-lactamase-producing and 50 beta-lactamase-producing strains of Neisseria gonorrhoeae serogroup WI and WII/III were tested in vitro by an agar dilution method against a panel of antibiotics including ciprofloxacin, ofloxacin and norfloxacin. All strains irrespective of beta-lactamase production and serogroup allocation, were inhibited by 0.125 mg/l of all quinolones. Ciprofloxacin turned out to be most active followed by ofloxacin and norfloxacin. All strains were also inhibited by low concentrations of cefotaxime (MIC less than 0.25 mg/l). Many strains mostly among the beta-lactamase-producing strains were resistant (MIC greater than 4 mg/l) to doxycycline. Ampicillin is still active against the majority of non-beta-lactamase-producing strains. The majority of the strains belonged to serogroup WII/III which are known to be less sensitive to penicillin G and ampicillin.
采用琼脂稀释法，在体外对100株不产β-内酰胺酶和50株产β-内酰胺酶的淋病奈瑟菌血清群WI和WII/III菌株进行了一组抗生素测试，这些抗生素包括环丙沙星、氧氟沙星和诺氟沙星。所有菌株，无论是否产β-内酰胺酶以及血清群分类如何，均被0.125mg/l的所有喹诺酮类药物抑制。结果表明，环丙沙星活性最强，其次是氧氟沙星和诺氟沙星。所有菌株也被低浓度的头孢噻肟抑制（最低抑菌浓度小于0.25mg/l）。许多菌株，主要是产β-内酰胺酶的菌株，对多西环素耐药（最低抑菌浓度大于4mg/l）。氨苄西林对大多数不产β-内酰胺酶的菌株仍然有效。大多数菌株属于血清群WII/III，已知该血清群对青霉素G和氨苄西林敏感性较低。
