Wimmer I, Hartmann T, Brustbauer R, Minear G, Dam K
Department of Internal Medicine II with Nuclear Medicine, Landesklinikum St. Pölten, St. Pölten, Austria.
Horm Metab Res. 2014 Sep;46(10):707-9. doi: 10.1055/s-0034-1377029. Epub 2014 Jun 30.
Autoimmune thyroiditis (AIT) is one of the most common autoimmune diseases; genetic as well as environmental factors contribute to its pathogenesis. The thyroid is the organ with the highest selenium content per unit weight. Selenium status appears to have an impact on the development of thyroid pathologies. We investigated a possible difference of selenium serum levels as a marker of nutritional selenium supply between patients with AIT in central Lower Austria and a matched group of healthy persons living in the same region. Selenium serum levels in the patients with AIT were 98.0 ± 15.6 μg/l. A significant difference to the matched group of normal persons, whose selenium serum levels were 103.2 ± 12.4 μg/l, could not be detected by the t-test (p>0.05). We considered the serum selenium levels to be indicators of selenium supply (by alimentation). A serum level of 120-160 μg/l of selenium represents the normal range. According to this, most patients and control persons showed mild to moderate selenium deficiency (80-120 μg/l selenium). Although our data present slightly higher selenium levels in normal persons than in patients with AIT, this weak and statistically insignificant trend is not sufficient to support the conclusion of a link between inadequate selenium supply and autoimmune thyroid disease.
自身免疫性甲状腺炎（AIT）是最常见的自身免疫性疾病之一；遗传因素和环境因素均参与其发病机制。甲状腺是单位重量含硒量最高的器官。硒状态似乎对甲状腺疾病的发展有影响。我们调查了奥地利下奥地利州中部AIT患者与居住在同一地区的匹配健康人群之间，作为营养性硒供应指标的血清硒水平可能存在的差异。AIT患者的血清硒水平为98.0±15.6μg/l。通过t检验未发现与匹配的正常人群（其血清硒水平为103.2±12.μg/l）有显著差异（p>0.05）。我们认为血清硒水平是硒供应（通过饮食）的指标。血清硒水平120 - 160μg/l代表正常范围。据此，大多数患者和对照者表现为轻度至中度硒缺乏（硒水平为80 - 120μg/l）。虽然我们的数据显示正常人的硒水平略高于AIT患者，但这种微弱且无统计学意义的趋势不足以支持关于硒供应不足与自身免疫性甲状腺疾病之间存在关联的结论。
