特非那定对正常受试者茶碱药代动力学及代谢无影响。
Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects.
作者信息
Brion N, Naline E, Beaumont D, Pays M, Advenier C
机构信息
Laboratoire de Pharmacologie et de Biochimie, Centre Hospitalier de Versailles, France.
出版信息
Br J Clin Pharmacol. 1989 Mar;27(3):391-5. doi: 10.1111/j.1365-2125.1989.tb05383.x.
The pharmacokinetics of oral theophylline (250 mg) and the production of its metabolites (3-methylxanthine, 1-methyluric acid, 1,3-dimethyluric acid) were studied before and after the administration of oral terfenadine (120 mg twice daily for 16 days) in 10 healthy volunteers. Comparison of volumes of distribution, elimination half-lives, areas under the plasma concentration-time curves, plasma clearance of theophylline and elimination of theophylline metabolites indicated that terfenadine had no significant effect on theophylline pharmacokinetics and metabolism.
在10名健康志愿者中，研究了口服特非那定（每日2次，每次120 mg，共16天）前后口服氨茶碱（250 mg）的药代动力学及其代谢产物（3-甲基黄嘌呤、1-甲基尿酸、1,3-二甲基尿酸）的生成情况。氨茶碱的分布容积、消除半衰期、血浆浓度-时间曲线下面积、血浆清除率以及氨茶碱代谢产物的消除情况的比较表明，特非那定对氨茶碱的药代动力学和代谢没有显著影响。
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