特非那定治疗支气管哮喘的随机对照试验。
Treatment of bronchial asthma with terfenadine; a randomized controlled trial.
作者信息
Taytard A, Beaumont D, Pujet J C, Sapene M, Lewis P J
机构信息
Service de Pneumologie, Hopital Xavier Arnozan, Centre Hospitalo-Universitaire de Bordeaux, Pessac, France.
出版信息
Br J Clin Pharmacol. 1987 Dec;24(6):743-6. doi: 10.1111/j.1365-2125.1987.tb03240.x.
Abstract
- Terfenadine, a histamine H1-receptor antagonist, was studied in 52 patients with stable mild perennial asthma with an allergic basis. 2. After a placebo run-in period, patients were randomly allocated to either terfenadine 120 mg twice daily or placebo. After 2 weeks they were crossed over to the other treatment. Forty-six patients completed the study. 3. Terfenadine was significantly more effective than placebo as measured by peak expiratory flows and by symptom scores. 4. These results suggest that histamine may play a more significant role in asthmatic bronchoconstriction than is currently recognised.
摘要
- 特非那定是一种组胺H1受体拮抗剂，对52例有过敏基础的稳定型轻度常年性哮喘患者进行了研究。2. 在经过安慰剂导入期后，患者被随机分为两组，一组每日两次服用120毫克特非那定，另一组服用安慰剂。2周后，他们交叉接受另一种治疗。46例患者完成了研究。3. 以呼气峰值流速和症状评分衡量，特非那定比安慰剂显著更有效。4. 这些结果表明，组胺在哮喘性支气管收缩中可能发挥比目前公认的更重要的作用。
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