Cornish Rahchell S, Bolam Kate A, Skinner Tina L
Centre for Research on Exercise, Physical Activity and Health, School of Human Movement Studies, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, Queensland, AUSTRALIA.
Med Sci Sports Exerc. 2015 Mar;47(3):468-75. doi: 10.1249/MSS.0000000000000429.
This study aimed to examine the acute effect of caffeine on exercise capacity, exercise-related fatigue, and functional performance in prostate cancer survivors.
In this randomized, placebo-controlled, double-blind crossover study, 30 prostate cancer survivors (age, 70.3 ± 7.7 yr; body mass, 80.5 ± 13.0 kg; mean ± SD) consumed 6.04 ± 0.16 mg·kg(-1) of anhydrous caffeine or a placebo 1 h before completing a battery of exercise capacity and functional performance tests. Testing sessions were separated by 3-4 wk. Immediate fatigue and perceived exertion were measured directly pre- and postexercise at both testing sessions.
Caffeine increased exercise capacity by 7.93 s (+3.0%; P = 0.010); however, postexercise fatigue and perception of exertion were comparable with the placebo session (P = 0.632 and P = 0.902, respectively). Increases in isometric grip strength trended toward significance in both dominant (+2.9%; P = 0.053) and nondominant (+2.1%; P = 0.061) hands in the caffeine trial compared with placebo. Caffeine ingestion did not result in improvements in performance for any of the remaining functional measures, including the timed up-and-go test, repeated chair stands, 6-m fast walk, and 6-m backward tandem walk. Systolic blood pressure and HR were significantly increased (P = 0.006 and P = 0.040, respectively) upon completion of the testing battery when compared with placebo.
Consumption of caffeine 1 h before exercise induced improvements in exercise capacity and muscular strength in prostate cancer survivors. However, there was no change in exercise-related fatigue when compared with placebo despite reduction in timed performance of the 400-m walk. Caffeine seems to enhance exercise tolerance through improved performance with no subsequent increase in fatigue or perception of exertion and may be an appropriate strategy to promote exercise participation in prostate cancer survivors.
本研究旨在探讨咖啡因对前列腺癌幸存者运动能力、运动相关疲劳和功能表现的急性影响。
在这项随机、安慰剂对照、双盲交叉研究中，30名前列腺癌幸存者（年龄70.3±7.7岁；体重80.5±13.0千克；均值±标准差）在完成一系列运动能力和功能表现测试前1小时，服用6.04±0.16毫克/千克的无水咖啡因或安慰剂。测试 sessions 间隔3 - 4周。在两个测试 sessions 的运动前后直接测量即时疲劳和主观用力程度。
咖啡因使运动能力提高了7.93秒（+3.0%；P = 0.010）；然而，运动后疲劳和主观用力程度与安慰剂组相当（分别为P = 0.632和P = 0.902）。与安慰剂相比，咖啡因试验中优势手（+2.9%；P = 0.053）和非优势手（+2.1%；P = 0.061）的等长握力增加趋势接近显著。摄入咖啡因并未使其余任何功能指标的表现得到改善，包括定时起立行走测试、重复椅子站立、6米快速行走和6米向后串联行走。与安慰剂相比，完成测试组后收缩压和心率显著升高（分别为P = 0.006和P = 0.040）。
运动前1小时摄入咖啡因可改善前列腺癌幸存者的运动能力和肌肉力量。然而，尽管400米步行的定时表现有所下降，但与安慰剂相比，运动相关疲劳并无变化。咖啡因似乎通过改善表现来提高运动耐力，且随后不会增加疲劳或主观用力程度，可能是促进前列腺癌幸存者运动参与的合适策略。
