Matsuki Chisa, To Masahiro, Kondo Yusuke, Sugiyama Hiroki, Yamamoto Yuko, Shimizu Tomoko, Kamata Yohei, Saruta Juri, Tsukinoki Keiichi
Neuro Endocrinol Lett. 2014;35(3):236-41.
The aim of this study was to assess the relationship between brain-derived neurotrophic factor (BDNF) and sex hormones (estradiol [E2] and progesterone), using saliva samples obtained from healthy women.
Forty female dental hygienist students were divided into groups according to being in the follicular phase or luteal phase. Saliva BDNF, E2, and progesterone levels were measured using a sandwich ELISA system. The correlation between these factors was analyzed using Spearman's index, and fluctuations of these levels in the whole menstrual cycle were investigated classifying the subjects by every 4 days according to the phase of their menstrual cycle.
Saliva BDNF variations strongly correlated with saliva E2 levels in the follicular phase (r = 0.721, p = 0.000) and luteal phase (r = 0.770, p = 0.000). The correlation coefficient showing the relationship between progesterone and BDNF levels in the luteal phase (r = 0.371, p = 0.157) was lower than that in the follicular phase (r = 0.631, p = 0.001). Moreover, the fluctuation of BDNF levels in the menstrual cycle followed a similar pattern to that of E2.
We found that saliva BDNF and E2 levels were closely related in healthy young women. In particular, for first time, that correlation was investigated throughout the menstrual cycle. Monitoring of saliva BDNF may yield insight into women's reproductive and mental health.
本研究旨在通过采集健康女性的唾液样本，评估脑源性神经营养因子（BDNF）与性激素（雌二醇[E2]和孕酮）之间的关系。
40名女性口腔卫生专业学生根据处于卵泡期或黄体期进行分组。使用夹心ELISA系统测量唾液中BDNF、E2和孕酮水平。使用Spearman指数分析这些因素之间的相关性，并根据月经周期阶段每4天将受试者分类，研究这些水平在整个月经周期中的波动情况。
在卵泡期（r = 0.721，p = 0.000）和黄体期（r = 0.770，p = 0.000），唾液BDNF变化与唾液E2水平密切相关。黄体期孕酮与BDNF水平之间的相关系数（r = 0.371，p = 0.157）低于卵泡期（r = 0.631，p = 0.001）。此外，月经周期中BDNF水平的波动与E2的波动模式相似。
我们发现健康年轻女性的唾液BDNF和E2水平密切相关。特别是首次在整个月经周期中研究了这种相关性。监测唾液BDNF可能有助于深入了解女性的生殖和心理健康。
