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炎症标志物与 2 型糖尿病风险：系统评价和荟萃分析。

Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis.

机构信息

Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, China.

出版信息

Diabetes Care. 2013 Jan;36(1):166-75. doi: 10.2337/dc12-0702.

DOI:10.2337/dc12-0702
PMID:23264288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3526249/
Abstract

OBJECTIVE

There has been growing evidence that inflammatory markers play a role in the development of type 2 diabetes. We aimed to systematically review prospective studies on the associations of elevated levels of interleukin-6 (IL-6) and C-reactive protein (CRP) with increased risk of type 2 diabetes by conducting a meta-analysis.

RESEARCH DESIGN AND METHODS

A systematic search of the PubMed, EMBASE, ISI Web of Knowledge, and Cochrane Library databases up until 10 February 2012 was conducted to retrieve prospective studies matched to search terms. We used generalized least-squares trend estimation to assess dose-response relationships. The summary risk estimates were pooled using either fixed-effects or random-effects models to incorporate between-study variation.

RESULTS

The meta-analysis, including 10 prospective studies, with a total of 19,709 participants and 4,480 cases, detected a significant dose-response association of IL-6 levels with type 2 diabetes risk (relative risk [RR] 1.31 [95% CI 1.17-1.46]). For CRP, the meta-analysis involving 22 cohorts, with a total of 40,735 participants and 5,753 cases, showed that elevated CRP levels were significantly associated with increased risk of type 2 diabetes (1.26 [1.16-1.37]), with the absence of publication bias. Sensitivity and subgroup analyses further supported the associations.

CONCLUSIONS

This meta-analysis provides further evidence that elevated levels of IL-6 and CRP are significantly associated with increased risk of type 2 diabetes.

摘要

目的

越来越多的证据表明炎症标志物在 2 型糖尿病的发生发展中起作用。我们旨在通过进行荟萃分析，系统地回顾白细胞介素-6（IL-6）和 C 反应蛋白（CRP）水平升高与 2 型糖尿病风险增加之间的前瞻性研究。

研究设计和方法

对 PubMed、EMBASE、ISI Web of Knowledge 和 Cochrane 图书馆数据库进行了系统检索，截至 2012 年 2 月 10 日，以检索符合检索条件的前瞻性研究。我们使用广义最小二乘法趋势估计来评估剂量-反应关系。使用固定效应或随机效应模型汇总汇总风险估计值，以纳入研究间的差异。

结果

荟萃分析包括 10 项前瞻性研究，共有 19709 名参与者和 4480 例病例，检测到 IL-6 水平与 2 型糖尿病风险之间存在显著的剂量-反应关系（相对风险 [RR] 1.31 [95%CI 1.17-1.46]）。对于 CRP，荟萃分析包括 22 个队列，共有 40735 名参与者和 5753 例病例，表明 CRP 水平升高与 2 型糖尿病风险增加显著相关（1.26 [1.16-1.37]），不存在发表偏倚。敏感性和亚组分析进一步支持了这些关联。

结论

这项荟萃分析提供了进一步的证据，表明升高的 IL-6 和 CRP 水平与 2 型糖尿病风险增加显著相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c029/3526249/7e620a6a8784/166fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c029/3526249/e777d415fc36/166fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c029/3526249/ba908378d28d/166fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c029/3526249/7e620a6a8784/166fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c029/3526249/e777d415fc36/166fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c029/3526249/ba908378d28d/166fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c029/3526249/7e620a6a8784/166fig3.jpg

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