Kennedy Kelsey M, Es'haghian Shaghayegh, Chin Lixin, McLaughlin Robert A, Sampson David D, Kennedy Brendan F
Opt Lett. 2014 May 15;39(10):3014-7. doi: 10.1364/OL.39.003014.
We present optical palpation, a tactile imaging technique for mapping micrometer- to millimeter-scale mechanical variations in soft tissue. In optical palpation, a stress sensor consisting of translucent, compliant silicone with known stress-strain behavior is placed on the tissue surface and a compressive load is applied. Optical coherence tomography (OCT) is used to measure the local strain in the sensor, from which the local stress at the sample surface is calculated and mapped onto an image. We present results in tissue-mimicking phantoms, demonstrating the detection of a feature embedded 4.7 mm below the sample surface, well beyond the depth range of OCT. We demonstrate the use of optical palpation to delineate the boundary of a region of tumor in freshly excised human breast tissue, validated against histopathology.
我们介绍了光学触诊技术，这是一种用于绘制软组织中微米级至毫米级机械变化的触觉成像技术。在光学触诊中，将一个由具有已知应力应变行为的半透明、柔顺硅胶制成的应力传感器放置在组织表面，并施加压缩载荷。光学相干断层扫描（OCT）用于测量传感器中的局部应变，由此计算出样品表面的局部应力并映射到图像上。我们展示了在组织模拟体模中的结果，证明能够检测到嵌入样品表面以下4.7毫米处的特征，这远远超出了OCT的深度范围。我们还展示了使用光学触诊来描绘新鲜切除的人类乳腺组织中肿瘤区域的边界，并与组织病理学结果进行了验证。
