Israelsson Axel, Pettersson Håkan
*Radiation Physics, Department of Medical and Health Sciences, Linköping University, Linköping SE 581 85, Sweden; †Radiation Physics, Department of Medical and Health Sciences, Linköping University, Department of Radiation Physics, Center for Surgery, Orthopaedics and Cancer Treatment, County Council of Östergötland, Linköping, SE 581 85, Sweden.
Health Phys. 2014 Aug;107(2):143-9. doi: 10.1097/HP.0000000000000075.
Hair is evaluated and compared with urine as a biomonitor for human intake of uranium. Concentrations of U and U and the activity ratio between them are measured in the hair, urine, and drinking water of 24 drilled bedrock well water users in Östergötland, Sweden. The samples are measured with α-spectrometry after radiochemical preparation using liquid-liquid separation with tributylphosphate. The results show that there is a stronger correlation between the uranium concentrations in the drinking water of each subject and the hair of the subject (r = 0.50) than with the urine (r = 0.21). There is also a stronger correlation between the activity ratios of water and hair (r = 0.91) than between water and urine (r = 0.56). These results imply that hair may serve as a robust indicator of chronic uranium intake. One obvious advantage over sampling urine is that hair samples reflect a much longer excretion period: weeks compared to days. The absorbed fraction of uranium, the f value, is calculated as the ratio between the excreted amount of uranium in urine and hair per day and the daily drinking water intake of uranium. The f values stretch from 0.002 to 0.10 with a median of 0.023.
头发作为人体摄入铀的生物监测指标，与尿液进行了评估和比较。对瑞典东约特兰省24名饮用基岩井水的人群的头发、尿液和饮用水中的铀-234、铀-238浓度及其活度比进行了测量。样品经过放射化学制备，采用磷酸三丁酯液-液分离法后，用α能谱法进行测量。结果表明，各受试者饮用水中的铀浓度与头发中的铀浓度之间的相关性（r = 0.50）比与尿液中的相关性（r = 0.21）更强。水与头发的活度比之间的相关性（r = 0.91）也比水与尿液的活度比之间的相关性（r = 0.56）更强。这些结果表明，头发可能是慢性铀摄入的可靠指标。与采集尿液相比，一个明显的优势是头发样本反映的排泄期长得多：以周计而非以天计。铀的吸收分数f值通过每天尿液和头发中铀的排泄量与每日饮用水中铀摄入量的比值来计算。f值范围为0.002至0.10，中位数为0.023。
