调节性 T 细胞与癌症：一种不理想的耐受。

Regulatory T cells and cancer: an undesired tolerance.

机构信息

1] Unité Mixte de Recherche INSERM 1098, Fédération Hospitalo-Universitaire INCREASE, Besançon, France [2] Université de Franche-Comté Institut Fédératif de Recherche 133, Besançon, France [3] Centre Hospitalier Universitaire, Besançon, France [4] Centre d'Investigation Clinique en Biothérapies 506, Besançon, France.

出版信息

Kidney Int. 2014 Jul;86(1):16-8. doi: 10.1038/ki.2014.46.

DOI:10.1038/ki.2014.46

PMID:24978377

Abstract

The incidence of cancer is markedly increased in organ transplant patients. A better understanding of underlying mechanisms and the identification of biomarkers for diagnosis and prognosis are major challenges. Hope et al. report expansion of regulatory T cells to be associated with the presence and severity of cancer. Although relevant, these results raise several questions.

摘要

器官移植患者的癌症发病率显著增加。更好地了解潜在机制和确定用于诊断和预后的生物标志物是主要挑战。Hope 等人报告调节性 T 细胞的扩增与癌症的存在和严重程度相关。虽然这些结果与癌症相关，但也提出了几个问题。