Esbenshade Adam J, Friedman Debra L, Smith Webb A, Jeha Sima, Pui Ching-Hon, Robison Leslie L, Ness Kirsten K
Department of Pediatrics (Drs Esbenshade and Friedman), Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee; Departments of Epidemiology and Cancer Control (Mr Smith and Drs Robison and Ness) and Oncology (Drs Jeha and Pui), St. Jude Children's Research Hospital, Memphis, Tennessee; Vanderbilt-Ingram Cancer Center (Drs Esbenshade and Friedman), Nashville, Tennessee.
Pediatr Phys Ther. 2014 Fall;26(3):301-7. doi: 10.1097/PEP.0000000000000053.
Children with acute lymphoblastic leukemia (ALL) are at increased risk of obesity and deconditioning from cancer therapy. This pilot study assessed feasibility/initial efficacy of an exercise intervention for patients with ALL undergoing maintenance therapy.
Participants were aged 5 to 10 years, receiving maintenance therapy, in first remission. A 6-month home-based intervention, with written and video instruction, was supervised with weekly calls from an exercise coach. Pre- and poststudy testing addressed strength, flexibility, fitness, and motor function.
Seventeen patients enrolled (participation 63%). Twelve (71%) finished the intervention, completing 81.7 ± 7.2% of prescribed sessions. Improvements of 5% or more occurred in 67% for knee and 75% for grip strength, 58% for hamstring/low-back and 83% for ankle flexibility, 75% for the 6-Minute Walk Test, and 33% for performance on the Bruininks-Oseretsky Test of Motor Proficiency Version 2.
This pilot study demonstrated that exercise intervention during ALL therapy is feasible and has promise for efficacy.
急性淋巴细胞白血病（ALL）患儿因癌症治疗而肥胖和身体机能下降的风险增加。这项初步研究评估了针对接受维持治疗的ALL患者进行运动干预的可行性/初步疗效。
参与者年龄在5至10岁之间，处于首次缓解期且正在接受维持治疗。一项为期6个月的居家干预，通过书面和视频指导，并由运动教练每周进行电话监督。研究前后的测试涉及力量、柔韧性、体能和运动功能。
17名患者入组（参与率63%）。12名（71%）完成了干预，完成了规定疗程的81.7±7.2%。膝关节力量提高5%或更多的占67%，握力提高5%或更多的占75%，腘绳肌/下背部柔韧性提高5%或更多的占58%，踝关节柔韧性提高5%或更多的占83%，6分钟步行测试成绩提高5%或更多的占75%，布吕尼inks-奥塞茨基运动熟练度测试第2版成绩提高5%或更多的占33%。
这项初步研究表明，ALL治疗期间的运动干预是可行的，且有望取得疗效。
