儿童急性淋巴细胞白血病维持治疗期间家庭锻炼的可行性及初步疗效
Feasibility and initial effectiveness of home exercise during maintenance therapy for childhood acute lymphoblastic leukemia.
作者信息
Esbenshade Adam J, Friedman Debra L, Smith Webb A, Jeha Sima, Pui Ching-Hon, Robison Leslie L, Ness Kirsten K
机构信息
Department of Pediatrics (Drs Esbenshade and Friedman), Vanderbilt University School of Medicine and the Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee; Departments of Epidemiology and Cancer Control (Mr Smith and Drs Robison and Ness) and Oncology (Drs Jeha and Pui), St. Jude Children's Research Hospital, Memphis, Tennessee; Vanderbilt-Ingram Cancer Center (Drs Esbenshade and Friedman), Nashville, Tennessee.
出版信息
Pediatr Phys Ther. 2014 Fall;26(3):301-7. doi: 10.1097/PEP.0000000000000053.
PURPOSE
Children with acute lymphoblastic leukemia (ALL) are at increased risk of obesity and deconditioning from cancer therapy. This pilot study assessed feasibility/initial efficacy of an exercise intervention for patients with ALL undergoing maintenance therapy.
METHODS
Participants were aged 5 to 10 years, receiving maintenance therapy, in first remission. A 6-month home-based intervention, with written and video instruction, was supervised with weekly calls from an exercise coach. Pre- and poststudy testing addressed strength, flexibility, fitness, and motor function.
RESULTS
Seventeen patients enrolled (participation 63%). Twelve (71%) finished the intervention, completing 81.7 ± 7.2% of prescribed sessions. Improvements of 5% or more occurred in 67% for knee and 75% for grip strength, 58% for hamstring/low-back and 83% for ankle flexibility, 75% for the 6-Minute Walk Test, and 33% for performance on the Bruininks-Oseretsky Test of Motor Proficiency Version 2.
CONCLUSIONS
This pilot study demonstrated that exercise intervention during ALL therapy is feasible and has promise for efficacy.
目的
急性淋巴细胞白血病（ALL）患儿因癌症治疗而肥胖和身体机能下降的风险增加。这项初步研究评估了针对接受维持治疗的ALL患者进行运动干预的可行性/初步疗效。
方法
参与者年龄在5至10岁之间，处于首次缓解期且正在接受维持治疗。一项为期6个月的居家干预，通过书面和视频指导，并由运动教练每周进行电话监督。研究前后的测试涉及力量、柔韧性、体能和运动功能。
结果
17名患者入组（参与率63%）。12名（71%）完成了干预，完成了规定疗程的81.7±7.2%。膝关节力量提高5%或更多的占67%，握力提高5%或更多的占75%，腘绳肌/下背部柔韧性提高5%或更多的占58%，踝关节柔韧性提高5%或更多的占83%，6分钟步行测试成绩提高5%或更多的占75%，布吕尼inks-奥塞茨基运动熟练度测试第2版成绩提高5%或更多的占33%。
结论
这项初步研究表明，ALL治疗期间的运动干预是可行的，且有望取得疗效。
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