血小板糖蛋白受体α2β1整合素及糖蛋白IIIa基因多态性与糖尿病视网膜病变的关联：来自3007名受试者的证据

Association of platelet glycoprotein receptor alpha2beta1 integrin and glycoprotein IIIa gene polymorphisms with diabetic retinopathy: evidence from 3007 subjects.

作者信息

Gong Jian-Yang, Deng Da-Tong, Sun Ye-Huan

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University , Hefei, Anhui , China .

出版信息

Curr Eye Res. 2015 May;40(5):476-83. doi: 10.3109/02713683.2014.932386. Epub 2014 Jun 30.

DOI:10.3109/02713683.2014.932386

PMID:24979111

Abstract

PURPOSE

Many epidemiological studies have evaluated associations of platelet glycoprotein receptor alpha2beta1 integrin (ITGA2) and glycoprotein IIIa (ITGB3) gene polymorphisms with diabetic retinopathy (DR), but the published data are inconclusive. The aim of the present study was to assess the associations by using meta-analysis.

METHODS

A comprehensive electronic search (PubMed, EMBASE, Elsevier Science Direct, CNKI and Wanfang) was carried out until 31 August 2013. Odds ratios (ORs) and its 95% confidence intervals (CIs) were used to assess the strength of the associations.

RESULTS

Nine studies including 1678 cases and 1329 controls were included in the meta-analysis. Meta-analysis was performed for ITGA2 gene BgI II polymorphism (7 studies including 758 cases and 570 controls) and ITGB3 gene PlA1/A2 polymorphism (4 studies including 1047 cases and 861 controls). Significant associations were found for BgI II (+ versus -: OR = 1.42, 95% CI = 1.06-1.90, p = 0.02; +/- + +/+ versus -/-: OR = 1.46, 95% CI = 0.99-2.15, p = 0.06; +/+ versus -/- + +/-: OR = 1.90, 95% CI = 1.35-2.67, p = 0.0003) and PlA1/A2 (A2 versus A1: OR = 0.74, 95% CI = 0.52-1.07, p = 0.11; A1A2 + A2A2 versus A1A1: OR = 0.80, 95% CI = 0.64-0.99, p = 0.04; A2A2 versus A1A1 + A1A2: OR = 0.45, 95% CI = 0.27-0.75, p = 0.002) polymorphisms.

CONCLUSION

This meta-analysis demonstrates that DR is associated with ITGA2 BgI II and ITGB3 PlA1/A2 polymorphisms.

摘要

目的

许多流行病学研究评估了血小板糖蛋白受体α2β1整合素（ITGA2）和糖蛋白IIIa（ITGB3）基因多态性与糖尿病视网膜病变（DR）的关联，但已发表的数据尚无定论。本研究的目的是通过荟萃分析评估这些关联。

方法

截至2013年8月31日进行了全面的电子检索（PubMed、EMBASE、爱思唯尔科学Direct、中国知网和万方）。比值比（OR）及其95%置信区间（CI）用于评估关联强度。

结果

荟萃分析纳入了9项研究，包括1678例病例和1329例对照。对ITGA2基因BgI II多态性（7项研究，包括758例病例和570例对照）和ITGB3基因PlA1/A2多态性（4项研究，包括1047例病例和861例对照）进行了荟萃分析。发现BgI II（+与-：OR = 1.42，95%CI = 1.06 - 1.90，p = 0.02；+/- + +/+与-/-：OR = 1.46，95%CI = 0.99 - 2.15，p = 0.06；+/+与-/- + +/-：OR = 1.90，95%CI = 1.35 - 2.67，p = 0.0003）和PlA1/A2（A2与A1：OR = 0.74，95%CI = 0.52 - 1.07，p = 0.11；A1A2 + A2A2与A1A1：OR = 0.80，95%CI = 0.64 - 0.99，p = 0.04；A2A2与A1A1 + A1A2：OR = 0.45，95%CI = 0.27 - 0.75，p = 0.002）多态性存在显著关联。