Reiner Alexander P, Agardh Elisabeth, Teramura Gayle, Gaur Prashart, Gaur Lakshmi K, Agardh Carl-David
Department of Epidemiology, University of Washington, Seattle, Washington, USA.
Thromb Haemost. 2003 Jan;89(1):142-8.
Genetic factors appear to contribute to the severity and progression of diabetic retinopathy. We assessed the associations of the C807T and Glu505Lys variants of the glycoprotein Ia (alpha(2) integrin) subunit of the platelet/endothelial collagen receptor and risk of retinopathy in a population-based survey of 288 diabetic patients in one Swedish community. Neither variant was associated with retinopathy risk overall. However, the 807T variant was associated with increased risk of severe retinopathy, and the association was modified by diabetes duration. Among patients with diabetes of longer duration (>/=25 years), the 807T variant was strongly associated with risk of severe retinopathy (odds ratio 7.49, 95% confidence interval 1.75 to 32.1). There was no association between the 807T variant and risk of severe retinopathy among patients with diabetes duration <25 years. The Lys505 variant of glycoprotein Ia was associated with an odds ratio for severe retinopathy of 1.88 (95% confidence interval 0.83 to 4.24). Overall, there was a significant interaction between glycoprotein Ia genotype and duration of diabetes on the risk of retinopathy (P-value for interaction = 0.019). These results suggest the hypothesis that genetic variation of platelet glycoprotein Ia may play a particularly important role during the advanced stages of diabetic retinopathy.
遗传因素似乎与糖尿病视网膜病变的严重程度和进展有关。在瑞典一个社区对288名糖尿病患者进行的一项基于人群的调查中，我们评估了血小板/内皮胶原受体糖蛋白Ia（α₂整合素）亚基的C807T和Glu505Lys变异与视网膜病变风险之间的关联。总体而言，这两种变异均与视网膜病变风险无关。然而，807T变异与严重视网膜病变风险增加相关，且这种关联受糖尿病病程影响。在病程较长（≥25年）的糖尿病患者中，807T变异与严重视网膜病变风险密切相关（比值比7.49，95%置信区间1.75至32.1）。在病程<25年的糖尿病患者中，807T变异与严重视网膜病变风险无关联。糖蛋白Ia的Lys505变异与严重视网膜病变的比值比为1.88（95%置信区间0.83至4.24）。总体而言，糖蛋白Ia基因型与糖尿病病程在视网膜病变风险方面存在显著交互作用（交互作用P值 = 0.019）。这些结果提示了一个假说，即血小板糖蛋白Ia的基因变异可能在糖尿病视网膜病变的晚期阶段发挥特别重要的作用。
