血小板活化因子在牛主动脉内皮细胞培养物中的细胞内作用证据。
Evidence for an intracellular action of platelet-activating factor in bovine cultured aortic endothelial cells.
作者信息
Stewart A G, Dubbin P N, Harris T, Dusting G J
机构信息
Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Br J Pharmacol. 1989 Mar;96(3):503-5. doi: 10.1111/j.1476-5381.1989.tb11845.x.
Abstract
Bovine culture endothelial cells (BAECs) generate platelet-activating factor (Paf) following activation by bradykinin (Bk 0.1 nM), the ionophore, A23187 (3 microM), and ATP (10 microM), but Paf is not released from the cells. These stimuli also elicit generation of prostacyclin (PGI2). The specific and competitive Paf receptor antagonists, WEB 2086 (0.1-1.0 microM) and CV 6209 (0.01-0.1 microM), inhibited Bk-, A23187- and, to a lesser extent, ATP-induced PGI2 generation but had no effect on basal PGI2 generation. These data suggest a role for intracellular Paf in signal transduction.
摘要
牛主动脉内皮细胞（BAECs）在被缓激肽（Bk 0.1 nM）、离子载体A23187（3 microM）和ATP（10 microM）激活后会产生血小板活化因子（Paf），但Paf不会从细胞中释放出来。这些刺激也会引发前列环素（PGI2）的生成。特异性和竞争性的Paf受体拮抗剂WEB 2086（0.1 - 1.0 microM）和CV 6209（0.01 - 0.1 microM）可抑制Bk、A23187以及在较小程度上抑制ATP诱导的PGI2生成，但对基础PGI2生成没有影响。这些数据表明细胞内Paf在信号转导中发挥作用。
相似文献
1
Evidence for an intracellular action of platelet-activating factor in bovine cultured aortic endothelial cells.血小板活化因子在牛主动脉内皮细胞培养物中的细胞内作用证据。
Br J Pharmacol. 1989 Mar;96(3):503-5. doi: 10.1111/j.1476-5381.1989.tb11845.x.
2
Intracellular platelet-activating factor regulates eicosanoid generation in guinea-pig resident peritoneal macrophages.细胞内血小板活化因子调节豚鼠腹膜常驻巨噬细胞中类花生酸的生成。
Br J Pharmacol. 1989 Sep;98(1):141-8. doi: 10.1111/j.1476-5381.1989.tb16874.x.
3
Significance of endothelial prostacyclin and nitric oxide in peripheral and pulmonary circulation.内皮前列环素和一氧化氮在体循环和肺循环中的意义。
Med Sci Monit. 2001 Jan-Feb;7(1):1-16.
4
Endothelium from diverse vascular sources synthesizes platelet-activating factor.来自不同血管来源的内皮细胞合成血小板活化因子。
Arteriosclerosis. 1988 May-Jun;8(3):321-31. doi: 10.1161/01.atv.8.3.321.
5
Platelet-activating factor may act as a second messenger in the release of icosanoids and superoxide anions from leukocytes and endothelial cells.
Proc Natl Acad Sci U S A. 1990 Apr;87(8):3215-9. doi: 10.1073/pnas.87.8.3215.
6
CV 6209 is a non-competitive antagonist of platelet-activating factor receptors on guinea-pig resident peritoneal macrophages.CV 6209是豚鼠腹腔常驻巨噬细胞上血小板活化因子受体的非竞争性拮抗剂。
Clin Exp Pharmacol Physiol. 1989 Nov;16(11):813-20. doi: 10.1111/j.1440-1681.1989.tb01520.x.
7
Production of platelet-activating factor by porcine brain microvascular endothelial cells in culture.培养的猪脑微血管内皮细胞产生血小板活化因子。
Thromb Haemost. 1995 Nov;74(5):1335-9.
8
Platelet-activating factor induced calcium mobilization and phosphoinositide metabolism in cultured bovine cerebral microvascular endothelial cells.血小板活化因子诱导培养的牛脑微血管内皮细胞中的钙动员和磷酸肌醇代谢。
Biochim Biophys Acta. 1994 Nov 10;1224(2):323-8. doi: 10.1016/0167-4889(94)90206-2.
9
Interaction of the Paf antagonist WEB 2086 and its hetrazepine analogues with human platelets and endothelial cells.血小板活化因子拮抗剂WEB 2086及其杂氮䓬类似物与人类血小板和内皮细胞的相互作用。
Br J Pharmacol. 1989 Oct;98(2):653-61. doi: 10.1111/j.1476-5381.1989.tb12640.x.
10
Thienopyridines: effects on cultured endothelial cells.
J Physiol Pharmacol. 1999 Dec;50(4):597-604.
引用本文的文献
1
Inhibition of prostaglandin G/H synthase unveils a potent effect of platelet activating factor on the permeability of bovine aortic endothelial cells to albumin.抑制前列腺素G/H合酶揭示了血小板活化因子对牛主动脉内皮细胞白蛋白通透性的强大作用。
Inflammation. 2002 Dec;26(6):253-8. doi: 10.1023/a:1021477316559.
2
Intracellular platelet-activating factor regulates eicosanoid generation in guinea-pig resident peritoneal macrophages.细胞内血小板活化因子调节豚鼠腹膜常驻巨噬细胞中类花生酸的生成。
Br J Pharmacol. 1989 Sep;98(1):141-8. doi: 10.1111/j.1476-5381.1989.tb16874.x.
3
Bradykinin-induced plasma exudation in guinea-pig airways: involvement of platelet activating factor.缓激肽诱导的豚鼠气道血浆渗出：血小板活化因子的作用。
Br J Pharmacol. 1990 Nov;101(3):739-45. doi: 10.1111/j.1476-5381.1990.tb14150.x.
4
5
Platelet-activating factor may participate in signal transduction processes in rabbit leukocytes.血小板活化因子可能参与兔白细胞的信号转导过程。
Lipids. 1991 Dec;26(12):1044-9. doi: 10.1007/BF02536499.
6
Calcium-dependent biosynthesis of platelet-activating factor by submandibular gland cells.下颌下腺细胞钙依赖性合成血小板活化因子
Biochem J. 1991 May 15;276 ( Pt 1)(Pt 1):175-82. doi: 10.1042/bj2760175.
7
Excitable membranes, lipid messengers, and immediate-early genes. Alteration of signal transduction in neuromodulation and neurotrauma.可兴奋膜、脂质信使与即早基因。神经调节和神经创伤中信号转导的改变。
Mol Neurobiol. 1992 Winter;6(4):407-24. doi: 10.1007/BF02757944.
本文引用的文献
1
Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes.氢化可的松和“大皮质素”可抑制酵母聚糖诱导的大鼠腹腔白细胞中溶血血小板活化因子的释放。
Life Sci. 1985 Apr 1;36(13):1225-31. doi: 10.1016/0024-3205(85)90266-8.
2
CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo.CV - 6209，一种在体外和体内均具有高效能的血小板活化因子拮抗剂。
J Pharmacol Exp Ther. 1987 Jul;242(1):263-8.
3
Pharmacological actions of WEB 2086, a new specific antagonist of platelet activating factor.血小板活化因子新型特异性拮抗剂WEB 2086的药理作用
J Pharmacol Exp Ther. 1987 Jun;241(3):974-81.
4
Perspectives in platelet-activating factor research.血小板活化因子研究的展望
Pharmacol Rev. 1987 Jun;39(2):97-145.
5
Endothelium-derived relaxing factor released from cultured cells: differentiation from nitric oxide.从培养细胞中释放的内皮源性舒张因子：与一氧化氮的区别。
Clin Exp Pharmacol Physiol. 1988 Feb;15(2):83-92. doi: 10.1111/j.1440-1681.1988.tb01049.x.
6
Differential effects of aspirin and dexamethasone on phospholipase A2 and C activities and arachidonic acid release from endothelial cells in response to bradykinin and leukotriene D4.
Prostaglandins. 1986 Nov;32(5):703-8. doi: 10.1016/0090-6980(86)90192-9.
7
Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate.培养的内皮细胞在组胺、缓激肽和三磷酸腺苷的作用下会合成血小板激活因子和前列环素。
J Clin Invest. 1985 Jul;76(1):271-80. doi: 10.1172/JCI111957.
8
Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages.血小板、多形核白细胞和巨噬细胞上血小板活化因子受体的特性研究。
Br J Pharmacol. 1988 Aug;94(4):1225-33. doi: 10.1111/j.1476-5381.1988.tb11642.x.
9
Intracellular pH changes of cultured bovine aortic endothelial cells in response to ATP addition.
Biochem Biophys Res Commun. 1988 May 16;152(3):1304-9. doi: 10.1016/s0006-291x(88)80427-3.
10
A radioimmunoassay for 6-keto-prostaglandin F1alpha.6-酮-前列腺素F1α的放射免疫测定法。
Prostaglandins. 1978 Mar;15(3):383-97. doi: 10.1016/0090-6980(78)90122-3.
Zotero 插件