Doganer Yusuf C, Aydogan Umit, Aparci Mustafa, Nerkiz Polat, Barcin Cem, Cayci Tuncer, Sari Oktay
aDepartment of Family Medicine, Mayo Clinic, Rochester, Minnesota, USA bDepartment of Family Medicine cDepartment of Cardiology dDepartment of Biochemistry, Gulhane Military Medical Faculty eDepartment of Cardiology, Etimesgut Military Hospital, Ankara fBalmumcu Family Health Center, Gumussuyu Military Hospital, Istanbul, Turkey.
Coron Artery Dis. 2014 Nov;25(7):589-94. doi: 10.1097/MCA.0000000000000132.
Inflammation is one of the numerous factors that promote atherosclerosis. Cystatin-C (Cys-C) and pentraxin-3 (PTX-3) predominantly play roles in inflammation. Thus, we evaluated whether these markers were related to the presence and severity of coronary artery disease (CAD).
Eighty-two stable patients who had undergone coronary angiography were enrolled in the study. Patients were diagnosed with significant (>50% stenosis) and nonsignificant (<50% stenosis) CAD. Patients with diabetes, chronic heart failure, chronic kidney disease, and so on were excluded from the study.
Patients without CAD had higher Cys-C levels compared with those with CAD (1338.96±396.71 vs. 853.69±406.72 ng/ml, P<0.001). However, the PTX-3 level was inversely lower in patients without CAD (110.40±48.10 vs. 149.46±49.44 pg/ml, P=0.001). The Cys-C level was found to be 677.11±335.56, 1024.18±401.21, and 1338.96±396.71 ng/ml in patients with significant CAD and nonsignificant CAD, and healthy individuals, respectively (P<0.001). The PTX-3 level was inversely reduced in these groups: 168.43±49.09, 131.14±43.10, and 110.40±48.10 pg/ml, respectively (P<0.001).
We observed that the levels of Cys-C and PTX-3 were inversely varied in the same study groups. These parameters may aid detection of the presence or identification of the severity of CAD when used in combination. Determinative values could exactly be described in the large study groups.
炎症是促进动脉粥样硬化的众多因素之一。胱抑素-C（Cys-C）和五聚素-3（PTX-3）主要在炎症中发挥作用。因此，我们评估了这些标志物是否与冠状动脉疾病（CAD）的存在和严重程度相关。
82例接受冠状动脉造影的稳定患者纳入本研究。患者被诊断为有显著（>50%狭窄）和无显著（<50%狭窄）CAD。患有糖尿病、慢性心力衰竭、慢性肾病等的患者被排除在研究之外。
无CAD的患者Cys-C水平高于有CAD的患者（1338.96±396.71对853.69±406.72 ng/ml，P<0.001）。然而，无CAD的患者PTX-3水平反而较低（110.40±48.10对149.46±49.44 pg/ml，P=0.001）。在有显著CAD、无显著CAD和健康个体中，Cys-C水平分别为677.11±335.56、1024.18±401.21和1338.96±396.71 ng/ml（P<0.001）。这些组中PTX-3水平反而降低：分别为168.43±49.09、131.14±43.10和110.40±48.10 pg/ml（P<0.001）。
我们观察到在同一研究组中Cys-C和PTX-3水平呈相反变化。这些参数联合使用时可能有助于检测CAD的存在或识别其严重程度。确切的决定值可在大型研究组中描述。
