Kravchun Pavlo G, Kadykova Olga I, Molotyagin Dmitry G
Kharkiv National Medical University, Kharkiv, Ukraine.
Wiad Lek. 2019;72(2):181-185.
Introduction: Recently great attention is paid to studying of coronary artery disease (CAD) pathogenesis against the background of the diabetes mellitus (DM). First of all, the question of an inflammatory component role in development of atherosclerosis in patients with DM 2 types is studied. One of new perspective markers of immune inflammation is pentraxin-3 (PTX-3). The aim of the study was to evaluate the nature of changes in the level of pentraxin-3 in patients with coronary artery disease, depending on the presence of type 2 diabetes mellitus and to investigate the nature of the relationship with metabolic parameters.
Materials and methods: Comprehensive examination of 110 patients with CAD was conducted. Patients were divided into groups depending on presence of type 2 DM: to the first group (n = 75) entered patients with CAD and type 2 DM , the group of comparison was made by 35 patients with CAD without type 2 DM. 25 almost healthy persons entered into control group.
Results: As a result of a research it is established the reliable increase in PTX-3 level in all patients with CAD in comparison with group of control for 65.40% . And in the conditions of the combined current of CAD and type 2 DM, PTX-3 level is for 80.14% higher, than in persons of control group. Also interrelation between PTX-3 and indicators of dcarbohydrate and lipidic exchanges were defines. According to the carried-out correlation analysis there was revealed existence of direct integral probable connections between PTX-3 level and levels of glucose (r = 0.41; p <0,05), insulin (r = 0.36; p <0,05), index of HOMA (r = 0.89; p <0,05), TG level (r = 0.74; p <0,05) and the return with the HDL (r = - 0.54; p <0,05).
Conclusions: In patients with CAD with the accompanying type 2 DM it is established higher PTX-3 level, than in patients without type 2 DM and control group that demonstrates autoimune link activation. In the examined patients PTX-3 level increase was associated with violation of lipid and carbohydrate exchanges.
引言：近年来，糖尿病（DM）背景下冠状动脉疾病（CAD）发病机制的研究备受关注。首先，研究了炎症成分在2型糖尿病患者动脉粥样硬化发展中的作用。免疫炎症的新的潜在标志物之一是五聚体-3（PTX-3）。本研究的目的是评估冠心病患者中五聚体-3水平变化的性质，取决于2型糖尿病的存在情况，并研究其与代谢参数的关系性质。
材料与方法：对110例CAD患者进行了全面检查。根据2型糖尿病的存在情况将患者分为几组：第一组（n = 75）为患有CAD和2型糖尿病的患者，对照组为35例无2型糖尿病的CAD患者。25名几乎健康的人进入对照组。
结果：研究结果表明，与对照组相比，所有CAD患者的PTX-3水平可靠地升高了65.40%。在CAD和2型糖尿病合并存在的情况下，PTX-3水平比对照组高80.14%。还确定了PTX-3与碳水化合物和脂质交换指标之间的相互关系。根据进行的相关性分析，发现PTX-3水平与血糖水平（r = 0.41；p <0.05）、胰岛素水平（r = 0.36；p <0.05）、HOMA指数（r = 0.89；p <0.05）、甘油三酯水平（r = 0.74；p <0.05）以及与高密度脂蛋白的相关性（r = -0.54；p <0.05）之间存在直接的整体可能联系。
结论：在伴有2型糖尿病的CAD患者中，PTX-3水平高于无2型糖尿病的患者和对照组，这表明自身免疫联系被激活。在受检患者中，PTX-3水平升高与脂质和碳水化合物交换的紊乱有关。
