Chang Gregory, Xia Ding, Chen Cheng, Madelin Guillaume, Abramson Steven B, Babb James S, Saha Punam K, Regatte Ravinder R
Department of Radiology, NYU Langone Medical Center, Center for Musculoskeletal Care, New York, New York, USA; Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, New York, New York, USA.
J Magn Reson Imaging. 2015 May;41(5):1311-7. doi: 10.1002/jmri.24683. Epub 2014 Jun 30.
To determine how subchondral bone microarchitecture is altered in patients with mild knee osteoarthritis.
This study had Institutional Review Board approval. We recruited 24 subjects with mild radiographic knee osteoarthritis and 16 healthy controls. The distal femur was scanned at 7T using a high-resolution 3D FLASH sequence. We applied digital topological analysis to assess bone volume fraction, markers of trabecular number (skeleton density), trabecular network osteoclastic resorption (erosion index), plate-like structure (surface), rod-like structure (curve), and plate-to-rod ratio (surface-curve ratio). We used two-tailed t-tests to compare differences between osteoarthritis subjects and controls.
7T magnetic resonance imaging (MRI) detected deterioration in subchondral bone microarchitecture in both medial and lateral femoral condyles in osteoarthritis subjects as compared with controls. This was manifested by lower bone volume fraction (-1.03% to -5.43%, P < 0.04), higher erosion index (+8.49 to +22.76%, P < 0.04), lower surface number (-2.31% to -9.63%, P < 0.007), higher curve number (+6.85% to +16.93%, P < 0.03), and lower plate-to-rod ratio (-7.92% to -21.71%, P < 0.05).
The results provide further support for the concept that poor subchondral bone quality is associated with osteoarthritis and may serve as a potential therapeutic target for osteoarthritis interventions. J. Magn. Reson. Imaging 2015;41:1311-1317. © 2014 Wiley Periodicals, Inc.
确定轻度膝关节骨关节炎患者的软骨下骨微结构如何改变。
本研究获得机构审查委员会批准。我们招募了24名轻度膝关节影像学骨关节炎患者和16名健康对照者。使用高分辨率3D FLASH序列在7T对股骨远端进行扫描。我们应用数字拓扑分析来评估骨体积分数、小梁数量标记（骨骼密度）、小梁网络破骨细胞吸收（侵蚀指数）、板状结构（表面）、杆状结构（曲线）以及板杆比（表面 - 曲线比）。我们使用双尾t检验来比较骨关节炎患者与对照者之间的差异。
与对照者相比，7T磁共振成像（MRI）检测到骨关节炎患者股骨内外侧髁的软骨下骨微结构均有恶化。表现为较低的骨体积分数（-1.03%至-5.43%，P < 0.04）、较高的侵蚀指数（+8.49至+22.76%，P < 0.04）、较低的表面数量（-2.31%至-9.63%，P < 0.007）、较高的曲线数量（+6.85%至+16.93%，P < 0.03）以及较低的板杆比（-7.92%至-21.71%，P < 0.05）。
这些结果为软骨下骨质量差与骨关节炎相关这一概念提供了进一步支持，并且可能作为骨关节炎干预的潜在治疗靶点。《磁共振成像杂志》2015年；41:1311 - 1317。© 2014威利期刊公司
