Pauly Hannah M, Larson Blair E, Coatney Garrett A, Button Keith D, DeCamp Charlie E, Fajardo Ryan S, Haut Roger C, Haut Donahue Tammy L
School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado.
Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado.
J Orthop Res. 2015 Dec;33(12):1835-45. doi: 10.1002/jor.22975. Epub 2015 Jul 17.
Subchondral bone is thought to play a significant role in the initiation and progression of the post-traumatic osteoarthritis. The goal of this study was to document changes in tibial and femoral subchondral bone that occur as a result of two lapine models of anterior cruciate ligament injury, a modified ACL transection model and a closed-joint traumatic compressive impact model. Twelve weeks post-injury bones were scanned via micro-computed tomography. The subchondral bone of injured limbs from both models showed decreases in bone volume and bone mineral density. Surgical transection animals showed significant bone changes primarily in the medial hemijoint of femurs and tibias, while significant changes were noted in both the medial and lateral hemijoints of both bones for traumatic impact animals. It is believed that subchondral bone changes in the medial hemijoint were likely caused by compromised soft tissue structures seen in both models. Subchondral bone changes in the lateral hemijoint of traumatic impact animals are thought to be due to transmission of the compressive impact force through the joint. The joint-wide bone changes shown in the traumatic impact model were similar to clinical findings from studies investigating the progression of osteoarthritis in humans.
软骨下骨被认为在创伤后骨关节炎的起始和进展中起重要作用。本研究的目的是记录因两种兔前交叉韧带损伤模型（改良的前交叉韧带横断模型和闭合性关节创伤性压缩冲击模型）导致的胫骨和股骨软骨下骨的变化。损伤后12周，通过微型计算机断层扫描对骨骼进行扫描。两种模型中受伤肢体的软骨下骨均显示骨体积和骨密度降低。手术横断组动物的骨变化主要发生在股骨和胫骨的内侧半关节，而创伤冲击组动物的两根骨头的内侧和外侧半关节均有明显变化。据信，内侧半关节的软骨下骨变化可能是由两种模型中均出现的软组织结构受损引起的。创伤冲击组动物外侧半关节的软骨下骨变化被认为是由于压缩冲击力通过关节传递所致。创伤冲击模型中显示的全关节骨变化与研究人类骨关节炎进展的临床研究结果相似。
