Bil-Lula Iwona, Stąpor Sylwia, Krzywonos-Zawadzka Anna, Woźniak Mieczysław
Department of Clinical Chemistry, Wroclaw Medical University, Poland.
Laboratory of Haematological and Transplant Diagnostics, University Hospital No 1, Wroclaw, Poland.
Adv Clin Exp Med. 2014 May-Jun;23(3):415-22. doi: 10.17219/acem/37139.
Obesity is a chronic disease of multiple etiologies. Alongside the traditionally recognized causes of obesity, such as genetic inheritance and behaviour/environmental factors, in recent years adenoviral infections have been considered as a possible cause of obesity. Although numerous studies involving animals confirmed a strong relation between adenoviral infection and increased predisposition to obesity, an association of AdVs with human obesity has not been established conclusively.
The main aim of this study was to establish an association between seroprevalence of adenoviruses and obesity in the Polish population.
Eighty-six subjects (both obese and non-obese) participated in this study. The presence and the concentration of typically non-specific antibodies to human adenoviruses in serum were determined using ELISA immunoassay. A serum lipid-profile was evaluated using commercial tests.
A total of 89.5% of subjects were positive for AdV-IgG (n = 77); 10.5% (n = 9) were negative. In non-obese or lean AdV-IgG positive subjects, the parameters as: body weight (63.5 vs. 57.0, p = 0.02), WHR (0.77 vs. 0.73, p = 0.02) and waist circumference (74.5 vs. 69.0, p = 0.01) were significantly higher as AdV-IgG negative individuals.
We showed that there is an association between the presence of type unspecific anti-AdV antibodies in the serum and elevated body weight, BMI, WHR and waist circumference in lean and non-obese subjects from the Polish population.
肥胖是一种多病因的慢性疾病。除了传统上公认的肥胖原因，如遗传和行为/环境因素外，近年来腺病毒感染被认为是肥胖的一个可能原因。尽管大量动物研究证实腺病毒感染与肥胖易感性增加之间存在密切关系，但腺病毒与人类肥胖之间的关联尚未得到最终证实。
本研究的主要目的是确定波兰人群中腺病毒血清阳性率与肥胖之间的关联。
86名受试者（包括肥胖和非肥胖者）参与了本研究。采用ELISA免疫分析法测定血清中针对人腺病毒的典型非特异性抗体的存在情况和浓度。使用商业检测方法评估血清脂质谱。
共有89.5%的受试者AdV-IgG呈阳性（n = 77）；10.5%（n = 9）呈阴性。在非肥胖或瘦的AdV-IgG阳性受试者中，体重（63.5对57.0，p = 0.02）、腰臀比（0.77对0.73，p = 0.02）和腰围（74.5对69.0，p = 0.01）等参数显著高于AdV-IgG阴性个体。
我们发现，波兰人群中瘦和非肥胖受试者血清中存在非特异性抗腺病毒抗体与体重、BMI、腰臀比和腰围升高之间存在关联。
