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A pilot study of stiripentol, a new anticonvulsant drug, in complex partial seizures uncontrolled by carbamazepine.

作者信息

Rascol O, Squalli A, Montastruc J L, Garat A, Houin G, Lachau S, Tor J, Blehaut H, Rascol A

机构信息

Service de Pharmacologie Médicale et Clinique INSERM U 317, Centre Hospitalier Universitaire, Faculté de Médecine, Toulouse, France.

出版信息

Clin Neuropharmacol. 1989 Apr;12(2):119-23. doi: 10.1097/00002826-198904000-00006.

DOI:10.1097/00002826-198904000-00006
PMID:2497976
Abstract
摘要

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1
A pilot study of stiripentol, a new anticonvulsant drug, in complex partial seizures uncontrolled by carbamazepine.
Clin Neuropharmacol. 1989 Apr;12(2):119-23. doi: 10.1097/00002826-198904000-00006.
2
Complex partial seizures: EEG foci and response to carbamazepine and sodium valproate.复杂部分性发作：脑电图病灶以及对卡马西平和丙戊酸钠的反应。
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Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid.苯妥英钠、卡马西平和司替戊醇联合治疗对丙戊酸肝毒性代谢产物4-烯-丙戊酸形成的影响。
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Balance and cognitive impairment in two epileptic patients before and after vagal nerve stimulation.两名癫痫患者在迷走神经刺激前后的平衡和认知障碍
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Use of total and free anticonvulsant serum levels in clinical practice.临床实践中总抗惊厥血清水平和游离抗惊厥血清水平的应用。
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Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.对人类颞叶癫痫有效的抗惊厥药物可预防癫痫发作，但不能预防喹啉酸在大鼠中诱发的神经毒性：脑电图、行为学和组织学评估。
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Single drug therapy for intractable epilepsy.难治性癫痫的单药治疗。
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Efficacy and tolerability of add-on stiripentol in real-world clinical practice: An observational study in Dravet syndrome and non-Dravet developmental and epileptic encephalopathies.附加型司替戊醇在真实临床实践中的疗效和耐受性：一项 Dravet 综合征和非 Dravet 发育性和癫痫性脑病的观察性研究。
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Stiripentol add-on therapy for drug-resistant focal epilepsy.
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Cochrane Database Syst Rev. 2022 Sep 6;9(9):CD009887. doi: 10.1002/14651858.CD009887.pub6.
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Stiripentol add-on therapy for drug-resistant focal epilepsy.司替戊醇添加疗法用于耐药性局灶性癫痫
Cochrane Database Syst Rev. 2020 May 26;5(5):CD009887. doi: 10.1002/14651858.CD009887.pub5.
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Stiripentol add-on therapy for focal refractory epilepsy.司替戊醇添加疗法治疗局灶性难治性癫痫。
Cochrane Database Syst Rev. 2018 May 10;5(5):CD009887. doi: 10.1002/14651858.CD009887.pub4.
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Drugs. 1994 Aug;48(2):153-71. doi: 10.2165/00003495-199448020-00003.