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Efficacy and side effects of flurazepam, fosazepam, and nitrazepam as sleeping aids in psychogeriatric patients.

作者信息

Viukari M, Linnoila M, Aalto U

出版信息

Acta Psychiatr Scand. 1978 Jan;57(1):27-35. doi: 10.1111/j.1600-0447.1978.tb06871.x.

DOI:10.1111/j.1600-0447.1978.tb06871.x
PMID:24980
Abstract

Efficacy and side effects of flurazepam 15 mg, fosazepam 60 mg, and nitrazepam 5 mg were studied in 17 psychogeriatric patients. The drugs were equipotent in maintaining sleep but nitrazepam had more side effects than the other hypnotics, and it induced a rebound insomnia after withdrawal. All hypnotics lost some of their efficacy towards the end of 7 days' administration. Patients with evident cerebrovascular disease were vulnerable to the side effects of the benzodiazepine hypnotics. The side effects did not correlate with the age of a patient. In addition, no correlations were found between the serum levels of fosazepam or its main metabolite and the side effects.

摘要

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