Modern analytical technologies for the detection of drug abuse and doping.

作者信息

Huestis Marilyn A, Smith Michael L

机构信息

Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.

Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, Rockville, MD 20850, USA.

出版信息

Drug Discov Today Technol. 2006 Spring;3(1):49-57. doi: 10.1016/j.ddtec.2006.03.004.

DOI:10.1016/j.ddtec.2006.03.004

PMID:24980101

Abstract

Consequences to individuals convicted of abusing prohibited drugs or doping agents can be severe, including loss of employment, child custody, driving privileges, right to compete in international sports and ultimately freedom, when mandatory confinement occurs. In view of these penalties, laboratories charged with providing evidence must maximize testing accuracy. False positive and false negative tests are prevented by combining sensitive immunoassays and specific chromatographic-mass spectrometric detection. In addition, testing different biological matrices offers unique information about the drug-use history of an individual.:

摘要