Jiwatram-Negrón Tina, El-Bassel Nabila
School of Social Work, Columbia University, 1255 Amsterdam Avenue, Room 825, New York City, NY, 10027, USA,
AIDS Behav. 2014 Oct;18(10):1864-87. doi: 10.1007/s10461-014-0827-7.
We conducted a systematic review of couple-based HIV biobehavioral (skills-building, VCT, and adherence) and biomedical (ART, circumcision) prevention and intervention studies designed to reduce sexual- and drug-risk behaviors and HIV transmission and acquisition. Of the 11,162 papers identified in the search, 93 peer-reviewed papers met the inclusion criteria and yielded a total of 33 studies conducted globally. Biobehavioral couple-based prevention and intervention studies have been efficacious in reducing sexual- and drug-risk behaviors, increasing access to HIV testing and care, and improving adherence. Biomedical couple-based studies were found to reduce HIV incidence among HIV-negative sex partners and viral load among HIV-positive partners. Despite much progress, couple-based HIV prevention and intervention studies remain limited; a number of methodological gaps exist and studies focusing on MSM, people who inject drugs, and sex workers are scarce.
我们对基于伴侣的HIV生物行为（技能培养、自愿咨询检测及依从性）和生物医学（抗逆转录病毒治疗、包皮环切术）预防及干预研究进行了系统综述，这些研究旨在减少性和毒品风险行为以及HIV传播与感染。在检索到的11162篇论文中，93篇经过同行评审的论文符合纳入标准，共产生了全球范围内开展的33项研究。基于伴侣的生物行为预防及干预研究在减少性和毒品风险行为、增加HIV检测及治疗可及性以及提高依从性方面已见成效。基于伴侣的生物医学研究被发现可降低HIV阴性性伴侣中的HIV发病率以及HIV阳性伴侣中的病毒载量。尽管取得了很大进展，但基于伴侣的HIV预防及干预研究仍然有限；存在一些方法学上的差距，且针对男男性行为者、注射吸毒者和性工作者的研究很少。
