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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Rosebrough R, McMurtry J, Steele N

USDA-Agricultural Research Service, Beltsville Agricultural Research Center, MD 20705.

Comp Biochem Physiol B. 1989;92(4):659-65.

Forty-eight chicks (21 days old) were implanted (+/- 50 mg 17-beta estradiol; EBI) and fed diets containing +/- 0.1% propylthiouracil (PTU) for 7 days to determine the role of gonadal hormones in the regulation of energy metabolism in the hypothyroid chick. 2. In vitro lipogenesis (IVL) and glucose production (NGP) were measured in liver explants. 3. Liver glycogen (GLY) metabolism was studied in particulate fractions (50,000 x g) of liver. 4. Glycogen synthetase activity (GLYSYN) was assayed in the presence of glucose-6-phosphate (G-6P; 0, 0.15 and 10 mM) to determine activation states. 5. PTU and EBI increased (P less than 0.05) both GLY concentration and GLYSYN activity in chicks but, did not increase G-6P activity ratios or the in vitro activation of GLYSYN. 6. Both PTU and EBI increased (P less than 0.05) IVL and NGP. 7. Estradiol magnifies the effects of PTU in chicks suggesting an interaction between thyroid status and gonadal function.

将48只雏鸡（21日龄）进行植入（±50毫克17-β雌二醇；EBI），并饲喂含±0.1%丙基硫氧嘧啶（PTU）的日粮7天，以确定性腺激素在甲状腺功能减退雏鸡能量代谢调节中的作用。2. 测定肝外植体中的体外脂肪生成（IVL）和葡萄糖生成（NGP）。3. 在肝脏的微粒体部分（50,000×g）研究肝糖原（GLY）代谢。4. 在存在葡萄糖-6-磷酸（G-6P；0、0.15和10毫摩尔）的情况下测定糖原合成酶活性（GLYSYN），以确定激活状态。5. PTU和EBI均增加（P＜0.05）雏鸡的GLY浓度和GLYSYN活性，但未增加G-6P活性比率或GLYSYN的体外激活。6. PTU和EBI均增加（P＜0.05）IVL和NGP。7. 雌二醇放大了PTU对雏鸡的影响，表明甲状腺状态与性腺功能之间存在相互作用。

Rosebrough R, McMurtry J, Steele N

USDA-Agricultural Research Service, Beltsville Agricultural Research Center, MD 20705.

Comp Biochem Physiol B. 1989;92(4):659-65.

Forty-eight chicks (21 days old) were implanted (+/- 50 mg 17-beta estradiol; EBI) and fed diets containing +/- 0.1% propylthiouracil (PTU) for 7 days to determine the role of gonadal hormones in the regulation of energy metabolism in the hypothyroid chick. 2. In vitro lipogenesis (IVL) and glucose production (NGP) were measured in liver explants. 3. Liver glycogen (GLY) metabolism was studied in particulate fractions (50,000 x g) of liver. 4. Glycogen synthetase activity (GLYSYN) was assayed in the presence of glucose-6-phosphate (G-6P; 0, 0.15 and 10 mM) to determine activation states. 5. PTU and EBI increased (P less than 0.05) both GLY concentration and GLYSYN activity in chicks but, did not increase G-6P activity ratios or the in vitro activation of GLYSYN. 6. Both PTU and EBI increased (P less than 0.05) IVL and NGP. 7. Estradiol magnifies the effects of PTU in chicks suggesting an interaction between thyroid status and gonadal function.

将48只雏鸡（21日龄）进行植入（±50毫克17-β雌二醇；EBI），并饲喂含±0.1%丙基硫氧嘧啶（PTU）的日粮7天，以确定性腺激素在甲状腺功能减退雏鸡能量代谢调节中的作用。2. 测定肝外植体中的体外脂肪生成（IVL）和葡萄糖生成（NGP）。3. 在肝脏的微粒体部分（50,000×g）研究肝糖原（GLY）代谢。4. 在存在葡萄糖-6-磷酸（G-6P；0、0.15和10毫摩尔）的情况下测定糖原合成酶活性（GLYSYN），以确定激活状态。5. PTU和EBI均增加（P＜0.05）雏鸡的GLY浓度和GLYSYN活性，但未增加G-6P活性比率或GLYSYN的体外激活。6. PTU和EBI均增加（P＜0.05）IVL和NGP。7. 雌二醇放大了PTU对雏鸡的影响，表明甲状腺状态与性腺功能之间存在相互作用。