Leszczynski D E, Toda T, Kummerow F A
Horm Metab Res. 1982 Apr;14(4):183-9. doi: 10.1055/s-2007-1018964.
The major ovarian hormones (estradiol and progesterone), the major testicular hormone (testosterone), and the major precursor to steroid hormones (cholesterol) were fed ad libitum in various combinations for either 2 weeks or 2 months (56 days) to 5-day-old female chicks; the effects of these treatments on liver lipids and plasma lipoproteins were measured. After two weeks, chicks fed basal diet supplemented with 0.05% estradiol had significant increases in plasma total cholesterol, triglycerides, and phospholipids (P less than .01). The combined supplementation of 0.05% estradiol plus 1% cholesterol produced an additive increase in plasma total cholesterol resulting in levels higher than obtained by either treatment alone (P less than .01). The addition of 0.2% progesterone to the 1% cholesterol diet inhibited the accumulation of plasma cholesterol (P less than .05), liver cholesterol (P less than .01), and liver triglycerides (P less than .01), which were found in comparable animals fed only 1% cholesterol. Likewise, the addition of 0.2% progesterone to diet containing 0.05% estradiol inhibited (P less than .01) accumulations in all of the plasma lipid classes which were found in comparable birds fed only 0.05% estradiol. After 2 months feeding, 0.1% testosterone had no effect on plasma or liver lipids. The combination of 0.05% estradiol plus 0.1% testosterone for 2 months was not very effective in reducing the hyperlipidemia caused by estradiol alone, but this treatment did result in a peculiar dwarf chicken. The results demonstrate strong steroid sex hormone interactions which produce major changes in chick plasma and liver lipid metabolism.
将主要的卵巢激素（雌二醇和孕酮）、主要的睾丸激素（睾酮）以及类固醇激素的主要前体（胆固醇）以各种组合随意投喂给5日龄的雌性雏鸡，投喂时间为2周或2个月（56天）；测定这些处理对肝脏脂质和血浆脂蛋白的影响。两周后，喂食添加0.05%雌二醇的基础日粮的雏鸡血浆总胆固醇、甘油三酯和磷脂显著增加（P<0.01）。0.05%雌二醇加1%胆固醇的联合添加使血浆总胆固醇呈相加性增加，导致其水平高于单独使用任一处理所获得的水平（P<0.01）。在含1%胆固醇的日粮中添加0.2%孕酮可抑制血浆胆固醇（P<0.05）、肝脏胆固醇（P<0.01）和肝脏甘油三酯（P<0.01）的积累，这些指标在仅喂食1%胆固醇的对照动物中有所升高。同样，在含0.05%雌二醇的日粮中添加0.2%孕酮可抑制（P<0.01）所有血浆脂质类别的积累，这些指标在仅喂食0.05%雌二醇的对照禽类中有所升高。喂食2个月后，0.1%睾酮对血浆或肝脏脂质无影响。0.05%雌二醇加0.1%睾酮联合处理2个月对单独由雌二醇引起的高脂血症的降低效果不佳，但这种处理确实导致了一种特殊的侏儒鸡。结果表明，类固醇性激素之间存在强烈的相互作用，可导致雏鸡血浆和肝脏脂质代谢发生重大变化。
