Favalessa Olivia Cometti, Lázera Márcia dos Santos, Wanke Bodo, Trilles Luciana, Takahara Doracilde Terumi, Tadano Tomoko, Dias Luciana Basili, Vieira Ananda Castro, Novack Glaúcia Vanessa, Hahn Rosane Christine
Laboratório de Micologia, Faculdade de Medicina, Universidade Federal de Mato Grosso, Cuiabá, MT, Brazil.
Mycoses. 2014 Oct;57(10):639-43. doi: 10.1111/myc.12210. Epub 2014 Jun 30.
Cryptococcus gattii, a species belonging to the Cryptococcus complex which occurs endemically in tropical and subtropical regions, has been reported as a causative agent of cryptococcosis in healthy individuals. We report a case of meningitis in HIV-negative patient from Cuiaba, MT, in the Midwestern region of Brazil. Cryptococcus gattii AFLP6/VGII was isolated from cerebrospinal fluid and molecular typing was performed by URA5-RFLP. The in vitro susceptibility profile was determined using the standard method according to the document M27A3, CLSI 2008. C. gattii AFLP6/VGII was shown to be susceptible to the antifungals tested. Treatment with 0.8 mg/kg of amphotericin B was initiated; however, the patient died 2 days after the onset of therapy.
加氏隐球菌是隐球菌复合体中的一个物种，在热带和亚热带地区呈地方性流行，已被报道为健康个体隐球菌病的病原体。我们报告了一例来自巴西中西部地区马托格罗索州库亚巴市的HIV阴性患者的脑膜炎病例。从脑脊液中分离出加氏隐球菌AFLP6/VGII，并通过URA5-RFLP进行分子分型。根据CLSI 2008年文件M27A3的标准方法测定体外药敏谱。结果显示加氏隐球菌AFLP6/VGII对所测试的抗真菌药物敏感。开始用0.8mg/kg的两性霉素B进行治疗；然而，患者在治疗开始后2天死亡。
