Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University.
Department of Infectious diseases, Rizhao Central Hospital, Rizhao, China.
Medicine (Baltimore). 2020 Dec 11;99(50):e23213. doi: 10.1097/MD.0000000000023213.
Cryptococcosis caused by Cryptococcus gattii, is a life threatening fungal infection with recently increasing prevalence. C. gattii is a species complex comprising multiple independent species. However, many biological characteristics and clinical features of cryptococcosis due to C. gattii are relatively less well defined. In this paper, we identify two cases of C. gattii infection, and laboratory findings of genotype VGI and VGII in two groups of apparently immunocompetent Chinese individuals respectively. Upon detailed review of all 35 cases of C. gattii infections, it was observed that C. gattii can cause debilitating illness in both immunocompetent and immunocompromised individuals. Cryptococcosis due to C. gattii is a serious systemic fungal infection, with pulmonary central nervous system tropism. Epidemiologically, C. gattii infection is not only restricted in tropical and subtropical regions, but also in other geographical settings.
新型隐球菌病是一种危及生命的真菌感染，其患病率呈上升趋势。新型隐球菌是一个种复合体，包含多个独立的种。然而，新型隐球菌病的许多生物学特性和临床特征尚不清楚。本文报道了两例新型隐球菌感染病例，两组免疫功能正常的中国个体分别为基因型 VGI 和 VGII。通过对 35 例新型隐球菌感染病例的详细回顾，发现新型隐球菌不仅可导致免疫功能正常个体，也可导致免疫功能低下个体罹患衰弱性疾病。新型隐球菌病是一种严重的系统性真菌感染，具有肺部和中枢神经系统嗜性。从流行病学角度来看，新型隐球菌感染不仅限于热带和亚热带地区，也存在于其他地理环境中。
