van Lenthe G Harry, Müller Ralph
Institute for Biomedical Engineering, University and ETH Zürich, Moussonstrasse 18, CH-8044 Zürich, Switzerland.
Institute for Biomedical Engineering, University and ETH Zürich, Moussonstrasse 18, CH-8044 Zürich, Switzerland.
Drug Discov Today Technol. 2006 Summer;3(2):221-9. doi: 10.1016/j.ddtec.2006.06.001.
Finite element analysis (FEA) is the method of choice to nondestructively quantify stresses and strains in bones. Moderate to good estimates of bone strength can be obtained from continuum-level FEA. Improved predictive capacity is expected from microstructural FE models that represent the trabecular architecture in detail. With the advent of recently developed high-resolution in vivo bone imaging systems and the steady increase in computational power, such microstructural FE analyses are now becoming available to estimate bone strength in humans in a clinical setting. The procedure can help improve predictions of fracture risk, clarify the pathophysiology of skeletal diseases, and monitor the response to therapy.:
有限元分析（FEA）是无损量化骨骼中应力和应变的首选方法。从连续体水平的有限元分析中可以获得对骨强度的中度到良好估计。详细表示小梁结构的微观结构有限元模型有望提高预测能力。随着最近开发的高分辨率体内骨成像系统的出现以及计算能力的稳步提高，现在可以在临床环境中进行这种微观结构有限元分析来估计人体的骨强度。该程序有助于改善骨折风险预测，阐明骨骼疾病的病理生理学，并监测治疗反应。
