16、18型人乳头瘤病毒在有患卵巢癌高风险女性上生殖道中的感染率
The frequency of human papilloma virus types 16, 18 in upper genital tract of women at high risk of developing ovarian cancer.
作者信息
Bilyk O O, Pande N T, Pejovic T, Buchinska L G
机构信息
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine.
Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon 97239, USA.
出版信息
Exp Oncol. 2014 Jun;36(2):121-4.
AIM
To investigate the incidence of human papilloma virus (HPV) types 16, 18 in upper genital tract of women considered at a high risk (HR) of developing epithelial ovarian cancer (EOC).
METHODS
HPV 16 and 18 E6 ORF specific semiquantitative PCR was used to screen the incidence of HPV in 20 women at HR of developing EOC and 10 women with no ovarian disease (control).
RESULTS
The HR subset of fallopian tubes and ovarian tissues showed greater positivity for HPV E6 ORF (40%) as compared to control (10%) tissues. Of all the samples, two (10%) were positive for HPV 16, two (10%) were positive for HPV 18, and four (20%) showed positivity for mixed HPV 16/18 infection. The presence of HPV E6 ORF was found both in the fallopian tubes and ovarian DNA from 6 (30%) patients. In two cases (10%) we detected HPV ORF only in the fallopian tube derived genomic DNA.
CONCLUSION
It has been shown the presence of HPV in the upper genital tract in women at HR of developing EOC in close proximity of HPV susceptible tissue cervix.
目的
研究在被认为患上皮性卵巢癌（EOC）风险较高（HR）的女性上生殖道中16、18型人乳头瘤病毒（HPV）的发生率。
方法
采用HPV 16和18 E6开放阅读框特异性半定量PCR检测20例患EOC风险较高的女性及10例无卵巢疾病女性（对照）中HPV的发生率。
结果
与对照组织（10%）相比，输卵管和卵巢组织的高风险亚组中HPV E6开放阅读框的阳性率更高（40%）。在所有样本中，2例（10%）HPV 16呈阳性，2例（10%）HPV 18呈阳性，4例（20%）显示为HPV 16/18混合感染阳性。6例（30%）患者的输卵管和卵巢DNA中均发现有HPV E6开放阅读框。在2例（10%）病例中我们仅在输卵管来源的基因组DNA中检测到HPV开放阅读框。
结论
研究表明，在患EOC风险较高的女性上生殖道中，HPV存在于靠近HPV易感组织宫颈的部位。
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