Collins Michael G, Rogers Natasha M, Jesudason Shilpanjali, Kireta Svjetlana, Brealey John, Coates Patrick Toby
Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia; Transplant Immunology Laboratory, Basil Hetzel Institute for Medical Research, The Queen Elizabeth Hospital, Woodville, SA, Australia; School of Medicine, University of Adelaide, Adelaide, SA, Australia.
J Med Primatol. 2014 Dec;43(6):477-87. doi: 10.1111/jmp.12134. Epub 2014 Jun 30.
Common marmosets are known to develop an IgM glomerulopathy, which has been linked with 'wasting marmoset' syndrome. This study investigated renal pathology in a colony of marmosets, with and without weight loss.
Renal histology, immunofluorescence, and electron microscopy were performed on marmosets euthanized for research or for weight loss. Serum and urine biochemistry were measured during life and at euthanasia.
Histology from 25 adult marmosets (19 research and 6 weight loss) showed mesangial expansion in the majority of glomeruli. Mesangial changes correlated with electron-dense deposits and IgM deposition by immunofluorescence; negligible other pathology was seen. Glomerular basement membrane thickness appeared increased compared to reported human measurements. Low-grade proteinuria was present in all animals, but did not progress. Renal function was normal in all animals.
Marmosets develop a glomerulopathy characterized by mesangial expansion, IgM deposition, and proteinuria. This is a benign occurrence and not specifically associated with weight loss.
已知普通狨猴会发生IgM肾小球病，该病与“消瘦狨猴”综合征有关。本研究调查了有体重减轻和无体重减轻的狨猴群体的肾脏病理学情况。
对因研究或体重减轻而实施安乐死的狨猴进行肾脏组织学、免疫荧光和电子显微镜检查。在生前和安乐死时检测血清和尿液生化指标。
25只成年狨猴（19只用于研究，6只体重减轻）的组织学检查显示，大多数肾小球系膜扩张。系膜变化与电子致密沉积物以及免疫荧光显示的IgM沉积相关；未见其他明显病理学改变。与报道的人类测量值相比，肾小球基底膜厚度似乎增加。所有动物均存在轻度蛋白尿，但未进展。所有动物的肾功能均正常。
狨猴会发生以系膜扩张、IgM沉积和蛋白尿为特征的肾小球病。这是一种良性情况，与体重减轻无特定关联。
