Department of Science and Mathematics, Texas A&M University San Antonio, San Antonio, Texas.
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas.
Am J Primatol. 2019 Feb;81(2):e22952. doi: 10.1002/ajp.22952. Epub 2019 Jan 21.
The development of the marmoset as a translational model for healthspan and lifespan studies relies on the characterization of health parameters in young and geriatric marmosets. This cross-sectional study examined health phenotypes in marmosets for five domains of interest for human health and aging: mobility, cognition, metabolism, homeostasis, and immune function. Geriatric marmosets were found to have significant executive function impairment when compared to young animals. While geriatric animals did not show gross abnormalities in mobility and measures of locomotion, their types of movement were altered from young animals. Geriatric marmosets had alterations in cardiac function, with significantly increased mean arterial pressures; metabolism, with significantly lower VO ; and suppressed immune function. Further, this study sought to characterize and describe histopathology for both young and geriatric healthy marmosets. Overall this study provides a characterization of health parameters for young and geriatric marmosets which will greatly enhance future aging and interventional testing in marmosets.
食蟹猴作为健康寿命和寿命研究的转化模型的发展依赖于对年轻和老年食蟹猴健康参数的特征描述。本横断面研究检查了五个与人类健康和衰老相关的感兴趣领域的食蟹猴健康表型：移动性、认知、代谢、内稳态和免疫功能。与年轻动物相比，老年食蟹猴的执行功能明显受损。虽然老年动物在移动性和运动测量方面没有明显的异常，但它们的运动类型与年轻动物不同。老年食蟹猴的心脏功能发生改变，平均动脉压显著升高；代谢方面，显著降低 VO；免疫功能受到抑制。此外，本研究旨在对年轻和老年健康食蟹猴进行组织病理学特征描述。总的来说，本研究对年轻和老年食蟹猴的健康参数进行了特征描述，这将极大地促进未来在食蟹猴中进行衰老和干预测试。
