Nodular intracerebral leukemic involvement in the course of acute nonlymphocytic leukemia. Case report and review of the literature.

A case of intracerebral nodular leukemic involvement arising during acute nonlymphocytic leukemia (ANLL)-M3 in complete remission is reported. Cerebrospinal fluid examination was normal. Computed tomography (CT) of the brain was consistent with nodular leukemic deposits. Cranial irradiation and intrathecal chemotherapy induced a complete resolution of the lesions. Twenty cases of nodular intracerebral leukemic involvement in ANLL are reviewed. About half of the patients with central nervous system (CNS) leukemia, when submitted systematically to neuroradiological investigations, presented intracerebral solid deposits. The value of CT scan is emphasized.