通过聚合酶链反应检测骨髓增生异常综合征和白血病中N-ras癌基因的突变
Mutations of N-ras oncogene in myelodysplastic syndromes and leukemias detected by polymerase chain reaction.
作者信息
Mano H, Ishikawa F, Hirai H, Takaku F
机构信息
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
出版信息
Jpn J Cancer Res. 1989 Feb;80(2):102-6. doi: 10.1111/j.1349-7006.1989.tb02274.x.
Abstract
By using polymerase chain reaction and differential hybridization, point mutations of N-ras oncogene were investigated among 43 patients with hematopoietic malignancies. Six cases were revealed to carry mutational N-ras oncogenes. One case with acute myelocytic leukemia was found to carry a mutation at codon 13, although this case was in complete remission.
摘要
通过聚合酶链反应和差异杂交技术，对43例造血系统恶性肿瘤患者的N-ras癌基因点突变进行了研究。发现6例携带N-ras癌基因突变。1例急性髓细胞白血病患者虽处于完全缓解期，但发现其第13密码子存在突变。
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