Nishida J, Hirai H, Takaku F
Biochem Biophys Res Commun. 1987 Sep 15;147(2):870-5. doi: 10.1016/0006-291x(87)91010-2.
The synthetic oligonucleotide probes were used for the analysis of N-ras oncogenes detected in human acute leukemias. The mutations of N-ras genes were observed to occur randomly among the subtypes of myeloid leukemias, whereas the N-ras mutations at codon 12 are more likely to occur in lymphoid leukemias than other mutations. The mutations at codon 13 of the N-ras gene were not detected in acute leukemias although they were found in myelodysplastic syndrome that is considered to be a preleukemic state.
合成寡核苷酸探针用于分析人类急性白血病中检测到的N-ras癌基因。观察到N-ras基因的突变在髓系白血病亚型中随机发生，而第12密码子处的N-ras突变在淋巴系白血病中比其他突变更易发生。N-ras基因第13密码子处的突变在急性白血病中未检测到，尽管在被认为是白血病前期状态的骨髓增生异常综合征中发现了这些突变。
