Snorradóttir Bergthóra S, Jónsdóttir Fjóla, Sigurdsson Sven Th, Másson Már
Faculty of Pharmaceutical Science, University of Iceland, Reykjavik, IS-107, Iceland.
J Pharm Sci. 2014 Aug;103(8):2366-75. doi: 10.1002/jps.24052. Epub 2014 Jul 1.
A model is presented for transdermal drug delivery from single-layered silicone matrix systems. The work is based on our previous results that, in particular, extend the well-known Higuchi model. Recently, we have introduced a numerical transient model describing matrix systems where the drug dissolution can be non-instantaneous. Furthermore, our model can describe complex interactions within a multi-layered matrix and the matrix to skin boundary. The power of the modelling approach presented here is further illustrated by allowing the possibility of a donor solution. The model is validated by a comparison with experimental data, as well as validating the parameter values against each other, using various configurations with donor solution, silicone matrix and skin. Our results show that the model is a good approximation to real multi-layered delivery systems. The model offers the ability of comparing drug release for ibuprofen and diclofenac, which cannot be analysed by the Higuchi model because the dissolution in the latter case turns out to be limited. The experiments and numerical model outlined in this study could also be adjusted to more general formulations, which enhances the utility of the numerical model as a design tool for the development of drug-loaded matrices for trans-membrane and transdermal delivery.
本文提出了一种用于单层硅酮基质系统经皮给药的模型。这项工作基于我们之前的研究成果，特别是对著名的Higuchi模型进行了扩展。最近，我们引入了一个数值瞬态模型来描述药物溶解可能非瞬时的基质系统。此外，我们的模型可以描述多层基质内部以及基质与皮肤边界之间的复杂相互作用。通过考虑供体溶液的可能性，进一步说明了本文所提出建模方法的强大之处。通过与实验数据进行比较，并使用含有供体溶液、硅酮基质和皮肤的各种配置相互验证参数值，对该模型进行了验证。我们的结果表明，该模型能够很好地近似实际的多层给药系统。该模型能够比较布洛芬和双氯芬酸的药物释放情况，而Higuchi模型无法分析这两种药物，因为在后者的情况下药物溶解是有限的。本研究中概述的实验和数值模型也可以调整为更通用的配方，这增强了数值模型作为设计工具在开发用于跨膜和经皮给药的载药基质方面的实用性。
