Carreras Núria, Alonso Cristina, Martí Meritxell, Lis Manel J
Department of Chemical Engineering, Polytechnic University of Catalonia , Barcelona , Spain .
J Microencapsul. 2015;32(4):358-63. doi: 10.3109/02652048.2015.1028495. Epub 2015 May 25.
Skin drug delivery can be subdivided into topical and transdermal administration. Transdermal administration can take advantage of chemical and physical strategies that can improve skin permeability and allow drug penetration. In this study, the development of a skin penetration profile was carried out by an in vitro technique for a microencapsulated system of ibuprofen. Release experiments were performed using percutaneous absorption tests to determine the evolution of the principle present in each of the different skin compartments as a function of time. A general kinetic model for a microencapsulated structure as a mass transport system through the skin was applied: [Formula: see text] This model could predict the penetration profile of encapsulated substances through skin from biofunctional textiles as well as estimate the dosage profile of the active principle. The apparent diffusion coefficients found were 1.20 × 10(-7 )cm/s for the stratum corneum and higher for the rest of the skin 6.67 × 10(-6 )cm/s.
皮肤给药可细分为局部给药和透皮给药。透皮给药可利用化学和物理策略来提高皮肤通透性并使药物渗透。在本研究中，通过体外技术对布洛芬微囊化系统进行了皮肤渗透曲线的研究。使用经皮吸收试验进行释放实验，以确定不同皮肤隔室中主要成分随时间的变化情况。应用了一个将微囊化结构作为通过皮肤的质量传输系统的通用动力学模型：[公式：见原文] 该模型可以预测包封物质从生物功能纺织品通过皮肤的渗透曲线，并估计活性成分的剂量曲线。角质层的表观扩散系数为1.20×10(-7)cm/s，皮肤其他部分的表观扩散系数更高，为6.67×10(-6)cm/s。
