Rattenbury J M, Timmins J G, Cawthorne E A, Ganapathy S, Taylor C J
Department of Chemical Pathology, Children's Hospital, Sheffield, England.
J Pediatr Gastroenterol Nutr. 1989 May;8(4):491-5. doi: 10.1097/00005176-198905000-00012.
Over a 2-month period, white deposits were found in infusion sets delivering parenteral nutrition mixtures that included a lipid emulsion. When components of the infusion were mixed in the laboratory, separation (creaming) of the emulsion could be demonstrated, and this enabled us to predict the concentrations of the prescribed infusates that were likely to cream. Further investigations showed that creaming occurred when the lipid emulsion was mixed with heparin and calcium ions at concentrations above 1 U/ml and 1 mumol/ml, respectively.
在两个月的时间里，在输注包含脂质乳剂的肠外营养混合物的输液装置中发现了白色沉积物。当在实验室中将输液的成分混合时，可以证明乳剂会出现分离（分层），这使我们能够预测可能会分层的规定输注液的浓度。进一步的研究表明，当脂质乳剂分别与浓度高于1 U/ml的肝素和浓度高于1 μmol/ml的钙离子混合时，就会发生分层。
