Málek Filip
Vnitr Lek. 2014 Apr;60(4):327-30.
Galectin 3 is a protein secreted by activated macrophages and has a role in development of fibrosis in injured tissues. Experimental studies showed increased galectin 3 secretion in the context of cardiac hypertrophy and heart failure models. Several clinical studies identified galectin 3 to be a biomarker of cardiovascular diseases in the field of diagnosis, risk stratification, monitoring therapy response and predicting short-term and long-term prognosis. Particularly, the additional prognostic information of galectin 3 as assessed together with NT-proBNP was established in acute and chronic heart failure.
半乳糖凝集素-3是一种由活化巨噬细胞分泌的蛋白质，在损伤组织的纤维化发展过程中发挥作用。实验研究表明，在心脏肥大和心力衰竭模型中，半乳糖凝集素-3的分泌增加。多项临床研究确定，在诊断、风险分层、监测治疗反应以及预测短期和长期预后等领域，半乳糖凝集素-3是心血管疾病的生物标志物。特别是，在急性和慢性心力衰竭中，已证实半乳糖凝集素-3与N末端B型利钠肽原（NT-proBNP）一起评估时具有额外的预后信息。
