神经胶质瘤的医学治疗
Medical therapy of gliomas.
作者信息
Ahluwalia Manmeet S, Chang Susan M
机构信息
The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
出版信息
J Neurooncol. 2014 Sep;119(3):503-12. doi: 10.1007/s11060-014-1495-1. Epub 2014 Jul 2.
Abstract
Medical therapies are an important part of adjunctive therapy for gliomas. In this chapter we will review the chemotherapeutic and targeted agents that have been evaluated in clinical trials in grade II-IV gliomas in the last decade. A number of randomized phase III trials were completed and reported. There has been a clear success in oligodendroglial tumors and low grade glioma. Although some progress has been made in glioblastoma, considerable work involving the multidisciplinary collaboration of basic science, translational and clinical investigators needs to be done to improve the outcome of patients with anaplastic astrocytoma and glioblastoma. In addition, tailoring treatment based on molecular cytogenetic characteristics is a major focus of research into precision based medicine for glioma.
摘要
医学治疗是胶质瘤辅助治疗的重要组成部分。在本章中，我们将回顾过去十年间在II-IV级胶质瘤临床试验中评估过的化疗药物和靶向药物。多项随机III期试验已完成并发表。少突胶质细胞瘤和低级别胶质瘤已取得明确成效。虽然胶质母细胞瘤已取得一些进展，但仍需要基础科学、转化医学和临床研究人员进行大量多学科合作的工作，以改善间变性星形细胞瘤和胶质母细胞瘤患者的治疗效果。此外，根据分子细胞遗传学特征定制治疗方案是胶质瘤精准医学研究的主要重点。
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