甲状腺抗体、自身免疫与认知功能衰退：基于人群的关联是否存在？
Thyroid antibodies, autoimmunity and cognitive decline: is there a population-based link?
作者信息
Napthali Kate, Boyle Michael, Tran Huy, Schofield Peter W, Peel Roseanne, McEvoy Mark, Oldmeadow Christopher, Attia John
机构信息
Division of Medicine, John Hunter Hospital, University of Newcastle, Newcastle, N.S.W., Australia.
Hunter Area Pathology Service, Newcastle, N.S.W., Australia.
出版信息
Dement Geriatr Cogn Dis Extra. 2014 May 21;4(2):140-6. doi: 10.1159/000362716. eCollection 2014 May.
BACKGROUND
Autoimmunity is considered an uncommon but under-recognised cause of cognitive decline.
METHODS
Serum samples from 3,253 randomly selected subjects enrolled in the Hunter Community Study, aged 55-85 years, were assayed for thyrotropin stimulatory hormone, anti-thyroid peroxidase antibodies (TPO-Ab), anti-nuclear antibodies (ANA) and extractable nuclear antigens (ENA). Cognitive function was assessed using the Audio Recorded Cognitive Screen (ARCS) tool.
RESULTS
TPO-Ab were found in 8.4% and ANA in 27.9% of the study population, of whom 3% had positive ENA findings. No relationship was found between the ARCS score and either TPO-Ab (coefficient = 0.133; 95% CI -0.20, 0.82, p = 0.616), ANA at a low (coefficient = 1.01; 95% CI -2.58, 0.55, p = 0.203) or a high titre (coefficient = -0.65; 95% CI -2.59, 1.28, p = 0.508), or ENA antibodies (coefficient = 5.12; 95% CI -0.53, 10.77; p = 0.076).
CONCLUSIONS
Autoantibody findings are common in an aging population and are not associated with cognitive decline.
背景
自身免疫被认为是认知功能下降的一个不常见但未被充分认识的原因。
方法
对从亨特社区研究中随机选取的3253名年龄在55 - 85岁的受试者的血清样本进行促甲状腺激素、抗甲状腺过氧化物酶抗体（TPO - Ab）、抗核抗体（ANA）和可提取核抗原（ENA）检测。使用音频记录认知筛查（ARCS）工具评估认知功能。
结果
在研究人群中，8.4%的人检测出TPO - Ab，27.9%的人检测出ANA，其中3%的人ENA检测结果为阳性。未发现ARCS评分与TPO - Ab（系数 = 0.133；95%置信区间 - 0.20，0.82，p = 0.616）、低滴度ANA（系数 = 1.01；95%置信区间 - 2.58，0.55，p = 0.203）或高滴度ANA（系数 = - 0.65；95%置信区间 - 2.59，1.28，p = 0.508）或ENA抗体（系数 = 5.12；95%置信区间 - 0.53，10.77；p = 0.076）之间存在关联。
结论
自身抗体检测结果在老年人群中很常见，且与认知功能下降无关。
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