Zhou Wenjianlong, Jiang Yuanwen, Xu Qin, Chen Liangpeng, Qiao Hui, Wang Yi-Xuan, Lai Jian-Cheng, Zhong Donglai, Zhang Yuan, Li Weining, Du Yanru, Wang Xuecheng, Lei Jiaxin, Dong Gehong, Guan Xiudong, Ma Shunchang, Kang Peng, Yuan Linhao, Zhang Milin, Tok Jeffrey B-H, Li Deling, Bao Zhenan, Jia Wang
Department of Neurosurgery, Beijing Tiantan Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China.
Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
Nat Biomed Eng. 2023 Oct;7(10):1270-1281. doi: 10.1038/s41551-023-01069-3. Epub 2023 Aug 3.
In microneurosurgery, it is crucial to maintain the structural and functional integrity of the nerve through continuous intraoperative identification of neural anatomy. To this end, here we report the development of a translatable system leveraging soft and stretchable organic-electronic materials for continuous intraoperative neurophysiological monitoring. The system uses conducting polymer electrodes with low impedance and low modulus to record near-field action potentials continuously during microsurgeries, offers higher signal-to-noise ratios and reduced invasiveness when compared with handheld clinical probes for intraoperative neurophysiological monitoring and can be multiplexed, allowing for the precise localization of the target nerve in the absence of anatomical landmarks. Compared with commercial metal electrodes, the neurophysiological monitoring system allowed for enhanced post-operative prognoses after tumour-resection surgeries in rats. Continuous recording of near-field action potentials during microsurgeries may allow for the precise identification of neural anatomy through the entire procedure.
在显微神经外科手术中，通过术中持续识别神经解剖结构来维持神经的结构和功能完整性至关重要。为此，我们在此报告一种可转化系统的开发，该系统利用柔软且可拉伸的有机电子材料进行术中连续神经生理监测。该系统使用具有低阻抗和低模量的导电聚合物电极，在显微手术期间连续记录近场动作电位，与用于术中神经生理监测的手持式临床探头相比，具有更高的信噪比和更低的侵入性，并且可以进行多路复用，从而在没有解剖标志的情况下实现目标神经的精确定位。与商用金属电极相比，该神经生理监测系统在大鼠肿瘤切除手术后可改善术后预后。在显微手术期间连续记录近场动作电位可能有助于在整个手术过程中精确识别神经解剖结构。
