眼部炎性疾病中的性别差异。
Gender disparities in ocular inflammatory disorders.
作者信息
Sen Hatice Nida, Davis Janet, Ucar Didar, Fox Austin, Chan Chi Chao, Goldstein Debra A
机构信息
National Eye Institute, National Institutes of Health , Bethesda, MD , USA .
出版信息
Curr Eye Res. 2015 Feb;40(2):146-61. doi: 10.3109/02713683.2014.932388. Epub 2014 Jul 2.
Abstract
Ocular inflammatory disorders disproportionately affect women, and the majority of affected women are of childbearing age. The role of sex or reproductive hormones has been proposed in many other inflammatory or autoimmune disorders, and findings from non-ocular autoimmune diseases suggest a complex interaction between sex hormones, genetic factors and the immune system. However, despite the age and sex bias, factors that influence this disparity are complicated and unclear. This review aims to evaluate the gender disparities in prevalence, incidence and severity of the most common infectious and non-infectious ocular inflammatory disorders.
摘要
眼部炎症性疾病对女性的影响尤为严重，且大多数受影响的女性处于育龄期。在许多其他炎症性或自身免疫性疾病中，已有人提出性别或生殖激素的作用，非眼部自身免疫性疾病的研究结果表明，性激素、遗传因素和免疫系统之间存在复杂的相互作用。然而，尽管存在年龄和性别偏差，但影响这种差异的因素复杂且尚不清楚。本综述旨在评估最常见的感染性和非感染性眼部炎症性疾病在患病率、发病率和严重程度方面的性别差异。
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